The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Circulating adrenaline and noradrenaline concentrations during exercise in patients with exercise induced asthma and normal subjects.
Open accessAbstract
A failure of the usual increase in plasma adrenaline and noradrenaline concentrations during submaximal exercise has been suggested as a contributory cause of exercise induced asthma. Six normal subjects and six asthmatic patients underwent a standard graded maximal exercise test. Measurements of oxygen consumption, minute ventilation, exercise time, blood lactate concentration, and heart rate indicated that the two groups achieved similarly high work loads during exercise. Mean FEV1 fell by 20% in asthmatic patients after exercise. Basal plasma adrenaline concentrations (nmol/l) increased in normal subjects from 0.05 to 2.7 and in asthmatic patients from 0.12 to 1.6 at peak exercise. Noradrenaline concentrations (nmol/l) increased in normal subjects from 2.0 to 14.3 and in asthmatic patients from 1.9 to 13.7 at peak exercise. The increases in adrenaline and noradrenaline in the asthmatic patients did not differ significantly from the increases in normal subjects. Thus a reduced sympathoadrenal response to exercise seems unlikely to be an important mechanism in the pathogenesis of exercise induced asthma.
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Adrenaline concentrations achieved during the infusion were similar to those observed during exercise.
“Adrenaline concentrations achieved during the infusion were similar to those observed during exercise21 (Figure 1E).”
From Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct (2017) · cites this paper as [21]
Citations
Cites
Clutter, W. E., Bier, D. M., Shah, S. D., & Cryer, P. E. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109840 · Cited by 576
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Research works printed but not linked: 22
- Barnes PJ, Brown MJ, Silverman M, Dollery CT. Circulating catecholamines in exercise and hyperventilation-induced asthma. Thorax 1981;36:435-40. · DOI
- Warren JB, Dalton N. A comparison of the bronchodilator and vaspressor effects of exercise levels of adrenaline in man. Clin Sci 1983;64:475-9. · DOI
- Bramnert M, Hokfelt B. Lack of effect of naloxone in a moderate dosage on the exercise-induced increase in blood pressure, heart rate, plasma catecholamines, plasma renin activity and plasma aldosterone in healthy males. Clin Sci 1985;68:185-91. · DOI
- Berkin KE, Inglis GC, Ball SG, Thomson NC. Airway responses to low concentrations of adrenaline and noradronaline in normal subjects. Q J Exp Physiol 1985;70:203-9. · DOI
- Berkin KE, Inglis GC, Ball SG, Thomson NC. Effect of low dose adrenaline and noradrenaline infusions on airway calibre in asthmatic patients. Clin Sci 1986; 70:347-52. · DOI
- Butchers PR, Skidmore IF, Vardey CJ, Wheeldon A. Characterisation of the receptor mediating antianaphylactic effects of beta-adrenoreceptor agonists in human lung tissues in vitro. Br J Pharmacol 1980; 71:663-7. · DOI
- Ito Y, Tajima K. Dual effects of catecholamines on preand post-junctional membranes in the dog trachea. Br J Pharmacol 1982;75:433-40. · DOI
- Danser AHJ, van den Ende R, Lorenz RR, Flavahan NA, Vanhoutte PM. Prejunctional beta-l-adrenoreceptors inhibit cholinergic transmission in canine bronchi. J Appl Physiol 1987;62:785-90. · DOI
- Warren JB, Keynes RJ, Brown MJ, Jenner DA, McNicol MW. Blunted sympathoadrenal response to exercise in asthmatic subjects. Br J Dis Chest 1982;76: 147-50. · DOI
- Larrson K, Hjemdahl P, Martinsson A. Sympathoadrenal reactivity in exercise-induced asthma. Chest 1982;23:297-303.
- Ball SG, Tree M, Morton JJ, Inglis GC, Fraser R. Circulating dopamine: its effects on the plasma concentrations of catecholamines, renin, angiotensin, aldosterone and vasopressin in the conscious dog. Clin Sci 1981;61:417-22. · DOI
- Jones PW, Wakefield JM, Kontaki E. A simple and portable paced step test for reproducible measurements of ventilation and oxygen consumption during exercise. Thorax 1987;42:136-43. · DOI
- Hadjivassiliou AG, Rieder SV. The enzymatic assay of pyruvic and lactic acids. A definitive procedure. Clin Chim Acta 1968;19:357-61. · DOI
- Dunnet CW. New tables for multiple comparisons with a control. Biometrics 1964;20:482-91. · DOI
- Cotes JE. Lung function: assessment and application in medicine. 4th ed. Oxford: Blackwell Scientific Publications, 1979.
- Warren JB, Dalton N, Turner C, Clark TJH, Toseland PA. Adrenaline secretion during exercise. Clin Sci 1984;66:87-90. · DOI
- Anderson SD, Pojer R, Smith ID, Temple D. Exercise related changes in plasma levels of 15-keto-13, 14dihydroprostaglandin F2 and noradrenaline in asthmatic and normal subjects. Scand J Respir Dis 1976; 57:41-8.
- Chryssanthopoulis C, Barboriak JJ, Fink JN, Stekial WJ, Maksud MG. Adrenergic responses of asthmatic and normal subjects to submaximal and maximal work levels. J Allergy Clin Immunol 1978;61:17-22. · DOI
- Ind PW, Brown MJ, Barnes PJ. Sympathoadrenal response in asthma [abstract]. Thorax 1983;38:702.
- Clarke B, Ind PW, Mair J, Causon R, Barnes PJ. Bronchodilator and catecholamine responses to induced hypoglycaemia in acute asthma [abstract]. Clin Sci 1985;69:35P. 22 Ind PW, Causon RC, Brown MJ, Barnes PJ. Circulating catecholamines in acute asthma. Br Med J 1985; 290:267-9.
- Bertel 0, BuhIer FR, Baitsch G, Ritz R, Bukart F. Plasma adrenaline and noradrenaline in patients with acute myocardial infarction. Chest 1982;82:64-8. · DOI
- Ind PW, Maxwell DL, Causon RC, Brown MJ, Barnes PJ. Hypoxia and catecholamine secretion in normal man [abstract]. Clin Sci 1984;67 (suppl 9):58P.
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Stimson, R. H., Anderson, A. J., Ramage, L. E., Macfarlane, D. P., de Beaux, A. C., Mole, D. J., Andrew, R., & Walker, B. R. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12899 · Cited by 63
Metadata
- Authors
- Berkin, K. E., Walker, G., Inglis, G. C., Ball, S. G., & Thomson, N. C.
- Affiliations
- Western Infirmary (GB)
- ORCID
- Thomson, N C
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1988-04-01
- Volume
- 43
- Issue
- 4
- Pages
- 295-299
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC461216
- OpenAlex
- W1991666887
- Cited by
- 31
- References
- 1
- Citations by year
- 2022: 2 · 2019: 1 · 2017: 2 · 2013: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- exercise-induced asthma, epinephrine, norepinephrine, sympathoadrenal response, plasma catecholamines, submaximal exercise, incremental exercise test, FEV1, asthma pathogenesis
- MeSH terms
- Adolescent, Adult, Asthma, Asthma, Exercise-Induced, Epinephrine, Physical Exertion, Humans, Lactates, Male, Norepinephrine
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