CoChat
Sign Up
Cited by 173Cystic Fibrosis Research AdvancesRespiratory viral infections researchPediatric health and respiratory diseases

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Effects of upper respiratory tract infections in patients with cystic fibrosis.

Open access
Collinson, J, Nicholson, K G, Cancio, E, Ashman, J, Ireland, D C, Hammersley, V, Kent, J, O'Callaghan, C·1996·Thorax
DOI 10.1136/thx.51.11.1115PMC PMC1090523
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: The polymerase chain reaction has improved the detection of picornaviruses and rhinoviruses and our understanding of their role in reversible airways disease. The effects of colds on lower respiratory morbidity and bacterial colonisation in cystic fibrosis remain uncertain. METHODS: Children with cystic fibrosis were evaluated regularly in the clinic and the parents notified the investigators when their child developed a cold. Nasopharyngeal specimens were collected at the start of the infection for polymerase chain reaction, bacteriology was also undertaken and again three weeks later, and pulmonary function was measured in children aged > or = 6 years at four day intervals for three weeks. The effects of colds on rate of progression of cystic fibrosis were assessed by pulmonary function, Shwachman scores, and radiology. RESULTS: Thirty eight children suffered 147 colds over 17 months. Picornaviruses were detected in 51 (43%) of 119 nasopharyngeal specimens, and 21 of the 51 were further identified as rhinoviruses. Pulmonary dysfunction was similar following picornavirus and non-picornavirus infections; the mean change from baseline in forced expiratory volume in one second (FEV1) was -16.5% and -10.3% at 1-4 days and 21-24 days, respectively, after onset of a cold. Children who experienced more colds than average had evidence of disease progression with reduction in Shwachman score, increasing Chrispin-Norman score, and greater deterioration in FEV1 per annum. Ten of 12 new bacterial infections were associated with a cold. CONCLUSIONS: Picornavirus and non-picornavirus colds are associated with pulmonary function abnormalities and disease progression in patients with cystic fibrosis, and predispose to secondary bacterial infection and colonisation.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/thx.51.11.1115

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 2

  1. Renzetti AD. Snowbird workshop in standardisation of spirometry: American Thoracic Society. Am Rev Respir Dis 1979;119:831-8.
  2. Zapletal A, Paul T, Samenek M. Die Bedeutung heutiger Methoden der Lungenfunktionsdiagnostik zur Festellung einer Obstruktion der Atemweger bei Kindern und Jugendlichen. Z Erkr Ata-Org 1977;149:343-71.

Cited by

Sorted by citations

See all 173

Related

See all

Metadata

Authors
Collinson, J., Nicholson, K. G., Cancio, E., Ashman, J., Ireland, D. C., Hammersley, V, Kent, J., & O'Callaghan, C.
Affiliations
University of Leicester (GB)
ORCID
Hammersley, V
Venue
Thorax
Publisher
BMJ
Published
1996-11-01
Volume
51
Issue
11
Pages
1115-1122
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.51.11.1115
PMC
PMC1090523
OpenAlex
W2138192279
Cited by
173
References
31
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
1.20
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Funders
Cystic Fibrosis Trust
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric health and respiratory diseases
Keywords
cystic fibrosis, upper respiratory tract infection, common cold, picornavirus, rhinovirus, lung function, disease progression, bacterial colonization, secondary bacterial infection, nasopharyngeal viral detection, children
MeSH terms
Adolescent, Bacterial Infections, Child, Child, Preschool, Common Cold, Cystic Fibrosis, Female, Forced Expiratory Volume, Humans, Infant, Male, Opportunistic Infections, Picornaviridae Infections, Respiratory Tract Infections, Vital Capacity, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review