Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats
Abstract
The purpose of this study was to investigate the cardioprotective effect of mangiferin on diabetic cardiomyopathy (DCM). The DCM model was induced by a high-fat diet and a low dose of streptozotocin. We evaluated the characteristics of DCM by serial echocardiography, electron microscopy, histopathologic analysis of cardiomyocyte fibrosis area, and Western blot analysis of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression. Rats with DCM showed severe left ventricular dysfunction and cardiac fibrosis. Mangiferin mitigated DCM and prevented the accumulation of myocardial collagen. These anatomic findings were accompanied by significant improvements in cardiac function. Based on these results, we conclude that mangiferin has a therapeutic effect on DCM and improves cardiac function.
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In a STZ-induced diabetic rat model, mangiferin (60 mg/kg; oral gavage for 12 weeks) reduces blood glucose and cardiomyocyte apoptosis, and downregulates inositol-requiring enzyme 1, apoptotic signal-regulating kinase and JNK.
“In a diabetic rat model induced by STZ, mangiferin (60 mg/kg; oral gavage for 12 weeks) reduces blood glucose and cardiomyocyte apoptosis, downregulates inositol-requiring enzyme 1, apoptotic signal-regulating kinase and JNK (43).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [43]
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- Authors
- Hou, J., Zheng, D., Zhong, G., & Hu, Y.
- Affiliations
- Chengdu Military General Hospital (CN)
- Chinese People's Liberation Army (CN)
- ORCID
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 2013-09
- Volume
- 91
- Issue
- 9
- Pages
- 759-763
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W2223495077
- Cited by
- 36
- References
- 20
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 5 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- mangiferin, diabetic cardiomyopathy, streptozotocin-induced diabetes, cardioprotection, myocardial fibrosis, MMP-2, MMP-9, left ventricular dysfunction, high-fat diet
- MeSH terms
- Animals, Cardiotonic Agents, Collagen, Diabetes Mellitus, Experimental, Fibrosis, Heart Ventricles, Male, Time Factors, Ultrasonography, Ventricular Function, Left, Rats, Sprague-Dawley, Ventricular Dysfunction, Left, Ventricular Remodeling, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Xanthones, Rats, Diabetic Cardiomyopathies, Diet, High-Fat
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