Wheel running prevents the accumulation of monounsaturated fatty acids in the liver of ovariectomized mice by attenuating changes in SCD-1 content
Abstract
Decreases in female sex steroids enhance the accumulation of visceral fat mass, leading to a predisposition to developing metabolic diseases. The purpose of this study was to determine whether loss of ovarian function alters the amount and (or) the fatty acid (FA) composition of triacylglycerol (TAG) levels in the liver of ovary-intact (SHAM) or ovariectomized (OVX) mice. We also sought to determine whether voluntary wheel running could attenuate the associated changes in the liver. Twenty-two C57/BL6 female mice were divided into 2 groups (SHAM, OVX) and were then subdivided into sedentary and exercising groups (SHAM-Sed, SHAM-Ex, OVX-Sed, OVX-Ex). Visceral fat mass significantly increased in the OVX-Sed animals; however, the effect was attenuated in the OVX-Ex animals. Total hepatic TAG content did not significantly increase in the OVX-Sed animals; however, SHAM-Ex and OVX-Ex animals demonstrated significant decreases in TAG levels. A significant increase in the FA desaturase index (18:1/18:0 and 16:1/16:0) was detected in the OVX-Sed animals compared with all other groups, which corresponded to increases in stearoyl-CoA desaturase (SCD-1) content. These results indicate that loss of ovarian function alters FA composition of hepatic TAG mediated by increases in SCD-1. These data indicate that female sex steroids influence lipid metabolism in the liver and provide important insight concerning the influence of exercise on hepatic function.
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Circulating androgen levels are critical for some of the behaviors assessed.
“Because circulating androgen levels are critical for some of these behaviors, the apparent lack of treatment effects was somewhat surprising.”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Jackson et al., 2011
The necessity of normal circulating levels of testosterone or estradiol for sex-typical running wheel activity is evident from the effects of adult or preweaning castration and/or exogenous replacement.
“For example, the necessity of normal circulating levels of testosterone or estradiol for sex-typical running wheel activity is clearly evident from the effects caused by adult or preweaning castration and/or exogenous replacement (Hagenauer et al., 2011;Ibebunjo et al., 2011;Jackson et al., 2011;Rivera and Eckel, 2005).”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Jackson et al., 2011
Cites
Increased visceral fat and decreased energy expenditure during the menopausal transition
Lovejoy, J. C., Champagne, C. M., de Jonge, L., Xie, H., & Smith, S. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.25 · Cited by 1,020 · see citing works
Rector, R. S., Thyfault, J. P., Laye, M. J., Morris, R. T., Borengasser, S. J., Uptergrove, G. M., Chakravarthy, M. V., Booth, F. W., & Ibdah, J. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156745 · Cited by 110 · see citing works
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Ferguson, S. A., Law, C. D., & Kissling, G. E. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu077 · Cited by 32 · see citing works
“For example, the necessity of normal circulating levels of testosterone or estradiol for sex-typical running wheel activity is clearly evident from the effects caused by adult or preweaning castration and/or exogenous replacement (Hagenauer et al., 2011; Ibebunjo et al., 2011; Jackson et al., 2011; Rivera and Eckel, 2…”
Background
- Authors
- Jackson, K. C., Wohlers, L. M., Valencia, A. P., Cilenti, M., Borengasser, S. J., Thyfault, J. P., & Spangenburg, E. E.
- Affiliations
- University of Maryland, College Park (US)
- University of Missouri (US)
- Harry S. Truman Memorial Veterans' Hospital (US)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2011-12
- Volume
- 36
- Issue
- 6
- Pages
- 798-810
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2099496723
- Cited by
- 21
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-000268)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- wheel running, ovariectomy, ovarian function, female sex hormones, stearoyl-CoA desaturase 1, monounsaturated fatty acids, hepatic triglycerides, visceral fat mass, hepatic lipid metabolism, physical activity, hepatic fatty acid composition
- MeSH terms
- Animals, Behavior, Animal, Diglycerides, Fatty Acids, Monounsaturated, Female, Hyperglycemia, Liver, Menopause, Mice, Inbred C57BL, Motor Activity, Ovariectomy, RNA, Messenger, Stearoyl-CoA Desaturase, Triglycerides, Gene Expression Regulation, Enzymologic, Intra-Abdominal Fat, Adiposity, Overweight, Diacylglycerol O-Acyltransferase, Mice
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