Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts
Abstract
The oxidative damage initiated by reactive oxygen species (ROS) is a major contributor to the functional decline and disability that characterizes aging. The anti-oxidant flavonoid, quercetin, is a plant polyphenol that may be beneficial for retarding the aging process. We examined the restoring properties of quercetin on human dermal fibroblasts (HDFs). Quercetin directly reduced either intracellular or extracellular ROS levels in aged HDFs. To find the aging-related target genes by quercetin, microarray analysis was performed and two up-regulated genes LPL and KCNE2 were identified. Silencing LPL increased the expression levels of senescence proteins such as p16 INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs. Silencing of LPL and KCNE2 decreased the expression levels of anti-oxidant enzymes such as superoxide dismutase and catalase. Also, the mitochondrial dysfunction in aged HDFs was ameliorated by quercetin treatment. Taken together, these results suggest that quercetin has restoring effect on the cellular senescence by down-regulation of senescence activities and up-regulation of the gene expressions of anti-oxidant enzymes in aged HDFs.
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Treatment with quercetin significantly lowers levels of ROS and inflammatory cytokines, reduces expression of SA-β gal, p16 and p53, and markedly increases that of antioxidant enzymes SOD and CAT, regardless of the type of oxidative trigger used to induce senescence.
“Results obtained on different cell lines show that treatment with quercetin significantly lowers the levels of ROS and inflammatory cytokines, reduces the expression of SA-β gal, p16 and p53 and markedly increases that of the antioxidant enzymes SOD and CAT, regardless of the type of oxidative trigger used to induce senescence [258,259,260,261,262].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [261]
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References 31 · Cited by 48
- Authors
- Sohn, E.-J., Kim, J. M., Kang, S.-H., Kwon, J., An, H. J., Sung, J.-S., Cho, K. A., Jang, I.-S., & Choi, J.-S.
- Affiliations
- Chungnam National University (KR)
- Genoplan Korea, Inc. and NAR Center, Inc., Seoul 06221, Republic of Korea
- Korea Basic Science Institute (KR)
- Dongguk University (KR)
- Chonnam National University (KR)
- Venue
- The American Journal of Chinese Medicine
- Publisher
- World Scientific Pub Co Pte Lt
- Published
- 2018-01
- Volume
- 46
- Issue
- 04
- Pages
- 853-873
- ISSN
- 0090-2942 (ISSN-L)
- 0192-415X
- 1793-6853
- OpenAlex
- W2800923315
- Cited by
- 48
- References
- 31
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 4
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Chinese Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- quercetin, cellular senescence, human dermal fibroblasts, aging, reactive oxygen species, oxidative stress, flavonoids, lipoprotein lipase, KCNE2, p16INK4a, p53, EGR1, superoxide dismutase, catalase, mitochondrial dysfunction, gene expression
- MeSH terms
- Antioxidants, Catalase, Cells, Cultured, Fibroblasts, Lipoprotein Lipase, Quercetin, Skin, Superoxide Dismutase, Up-Regulation, Gene Expression, Tumor Suppressor Protein p53, Cellular Senescence, Reactive Oxygen Species, Cyclin-Dependent Kinase Inhibitor p16, Gene Silencing, Potassium Channels, Voltage-Gated, Early Growth Response Protein 1
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