The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Assembly of Fibronectin Extracellular Matrix
Open accessAbstract
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks. Matrix assembly is usually initiated by ECM glycoproteins binding to cell surface receptors, such as fibronectin (FN) dimers binding to α5β1 integrin. Receptor binding stimulates FN self-association mediated by the N-terminal assembly domain and organizes the actin cytoskeleton to promote cell contractility. FN conformational changes expose additional binding sites that participate in fibril formation and in conversion of fibrils into a stabilized, insoluble form. Once assembled, the FN matrix impacts tissue organization by contributing to the assembly of other ECM proteins. Here, we describe the major steps, molecular interactions, and cellular mechanisms involved in assembling FN dimers into fibrillar matrix while highlighting important issues and major questions that require further investigation.
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Extracellular Matrix Assembly: A Multiscale Deconstruction
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Role of Extracellular Matrix in Development and Cancer Progression
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin
Erdogan, B., Ao, M., White, L. M., Means, A. L., Brewer, B. M., Yang, L., Washington, M. K., Shi, C., Franco, O. E., Weaver, A. M., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201704053 · Cited by 552
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Metadata
- Authors
- Singh, P., Carraher, C., & Schwarzbauer, J. E.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2010-11-10
- Volume
- 26
- Issue
- 1
- Pages
- 397-419
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2146453842
- Cited by
- 960
- References
- 133
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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