The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
A Decade of Systems Biology
Open accessAbstract
Systems biology provides a framework for assembling models of biological systems from systematic measurements. Since the field was first introduced a decade ago, considerable progress has been made in technologies for global cell measurement and in computational analyses of these data to map and model cell function. It has also greatly expanded into the translational sciences, with approaches pioneered in yeast now being applied to elucidate human development and disease. Here, we review the state of the field with a focus on four emerging applications of systems biology that are likely to be of particular importance during the decade to follow: (a) pathway-based biomarkers, (b) global genetic interaction maps, (c) systems approaches to identify disease genes, and (d) stem cell systems biology. We also cover recent advances in software tools that allow biologists to explore system-wide models and to formulate new hypotheses. The applications and methods covered in this review provide a set of prime exemplars useful to cell and developmental biologists wishing to apply systems approaches to areas of interest.
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Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
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A N EW A PPROACH TO D ECODING L IFE : Systems Biology
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A genome-wide atlas of co-essential modules assigns function to uncharacterized genes
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Metadata
- Authors
- Chuang, H.-Y., Hofree, M., & Ideker, T.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2010-11-10
- Volume
- 26
- Issue
- 1
- Pages
- 721-744
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2139070508
- Cited by
- 319
- References
- 25
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
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