The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Advances and New Directions in Crystallization Control
Abstract
The academic literature on and industrial practice of control of solution crystallization processes have seen major advances in the past 15 years that have been enabled by progress in in-situ real-time sensor technologies and driven primarily by needs in the pharmaceutical industry for improved and more consistent quality of drug crystals. These advances include the accurate measurement of solution concentrations and crystal characteristics as well as the first-principles modeling and robust model-based and model-free feedback control of crystal size and polymorphic identity. Research opportunities are described in model-free controller design, new crystallizer designs with enhanced control of crystal size distribution, strategies for the robust control of crystal shape, and interconnected crystallization systems for multicomponent crystallization.
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Cites
Some problems in particle technology
Hulburt, H. M., & Katz, S. (1964) · Chemical Engineering Science · doi:10.1016/0009-2509(64)85047-8 · Cited by 1,670
Cited by
Opportunities and challenges of real-time release testing in biopharmaceutical manufacturing
Jiang, M., Severson, K. A., Love, J. C., Madden, H., Swann, P., Zang, L., & Braatz, R. D. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26383 · Cited by 118
Self-citationSimone, E., Zhang, W., & Nagy, Z. K. (2016) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4743 · Cited by 24
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Metadata
- Authors
- Nagy, Z. K., & Braatz, R. D.
- Venue
- Annual Review of Chemical and Biomolecular Engineering
- Publisher
- Annual Reviews
- Published
- 2012-07-15
- Volume
- 3
- Issue
- 1
- Pages
- 55-75
- ISSN
- 1947-5438 (ISSN-L)
- 1947-5446
- OpenAlex
- W2168614130
- Cited by
- 332
- References
- 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Advances and New Directions in Crystallization Control. https://app.cochat.ai/papers/10.1146/annurev-chembioeng-062011-081043
- The paper
- Nagy, Z. K., & Braatz, R. D. (2012). Advances and New Directions in Crystallization Control. Annual Review of Chemical and Biomolecular Engineering. https://doi.org/10.1146/annurev-chembioeng-062011-081043
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
