The Global Expansion of Dengue: How Aedes aegypti Mosquitoes Enabled the First Pandemic Arbovirus
Abstract
Dengue is an emerging viral disease principally transmitted by the Aedes ( Stegomyia ) aegypti mosquito. It is one of the fastest-growing global infectious diseases, with 100-400 million new infections a year, and is now entrenched in a growing number of tropical megacities. Behind this rapid rise is the simple adaptation of Ae. aegypti to a new entomological niche carved out by human habitation. This review describes the expansion of dengue and explores how key changes in the ecology of Ae. aegypti allowed it to become a successful invasive species and highly efficient disease vector. We argue that characterizing geographic heterogeneity in mosquito bionomics will be a key research priority that will enable us to better understand future dengue risk and design control strategies to reverse its global spread.
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Alien species can vector pathogens.
“Moreover, alien species can vector pathogens (e.g. tiger mosquito, Aedes albopictus, for dengue fever; Hulme, 2014b ; Brady & Hay, 2020), produce allergenic pollen (common ragweed, Ambrosia artemisiifolia; Richter et al., 2013), and be poisonous (e.g. cane toad; Bacher et al., 2018) or venomous (e.g. sea jellies; Kideys & Gucu, 1995).”
From Scientists' warning on invasive alien species (2020) · cites this paper as Brady & Hay, 2020
Cites
The global distribution and burden of dengue
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DISPERSAL OF THE DENGUE VECTOR AEDES AEGYPTI WITHIN AND BETWEEN RURAL COMMUNITIES
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“Understanding geographic variation in mosquito survival, biting behavior, connectedness, and population dynamics is essential for understanding why new and existing vector control tools work in some places but not others (14).”
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Scientists' warning on invasive alien species
Pyšek, P., Hulme, P. E., Simberloff, D., Bacher, S., Blackburn, T. M., Carlton, J. T., Dawson, W., Essl, F., Foxcroft, L. C., Genovesi, P., et al. (2020) · Biological Reviews · doi:10.1111/brv.12627 · Cited by 2,234 · see citing works
- Authors
- Brady, O. J., & Hay, S. I.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- University of Washington (US)
- Venue
- Annual Review of Entomology
- Publisher
- Annual Reviews
- Published
- 2020-01-07
- Volume
- 65
- Issue
- 1
- Pages
- 191-208
- ISSN
- 0066-4170 (ISSN-L)
- 1545-4487
- OpenAlex
- W2979824923
- Cited by
- 405
- References
- 5
- Citations by year
- 2026: 48 · 2025: 61 · 2024: 84 · 2023: 71 · 2022: 56 · 2021: 47 · 2020: 34 · 2019: 3
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Entomology (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Funders
- Wellcome Trust (206471/Z/17/Z)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Social Sciences › Sociology and Political Science › Dengue and Mosquito Control Research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Diptera species taxonomy and behavior
- Keywords
- dengue, Aedes aegypti, mosquito vectors, invasive species, mosquito bionomics, urbanization, geographic heterogeneity, dengue risk, vector control, emerging infectious diseases
- MeSH terms
- Mosquito Vectors, Aedes, Animals, Dengue, Dengue Virus, Animal Distribution
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