Cited by 298Subterranean biodiversity and taxonomyRetinal Development and DisordersDevelopmental Biology and Gene Regulation

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Regressive Evolution in Astyanax Cavefish

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Jeffery, William R.·2009·Annual Review of Genetics

DOI 10.1146/annurev-genet-102108-134216PMC PMC3594788

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Abstract

A diverse group of animals, including members of most major phyla, have adapted to life in the perpetual darkness of caves. These animals are united by the convergence of two regressive phenotypes, loss of eyes and pigmentation. The mechanisms of regressive evolution are poorly understood. The teleost Astyanax mexicanus is of special significance in studies of regressive evolution in cave animals. This species includes an ancestral surface dwelling form and many con-specific cave-dwelling forms, some of which have evolved their recessive phenotypes independently. Recent advances in Astyanax development and genetics have provided new information about how eyes and pigment are lost during cavefish evolution; namely, they have revealed some of the molecular and cellular mechanisms involved in trait modification, the number and identity of the underlying genes and mutations, the molecular basis of parallel evolution, and the evolutionary forces driving adaptation to the cave environment.

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Authors: Jeffery, W. R.
Affiliations: University of Maryland, College Park (US)
Corresponding author: Jeffery, William R.
ORCID: Jeffery, William R.
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 2009-12-01
Volume: 43
Issue: 1
Pages: 25-47
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev-genet-102108-134216
PMC: PMC3594788
OpenAlex: W2121610939
Cited by: 298
References: 68
Citations by year: 2026: 15 · 2025: 21 · 2024: 15 · 2023: 20 · 2022: 20 · 2021: 18 · 2020: 28 · 2019: 16 · 2018: 28 · 2017: 14 · 2016: 13 · 2015: 14 · 2014: 16 · 2013: 25 · 2012: 13
FWCI: 1.21
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
Funders: National Science Foundation
Fordham University
National Institutes of Health
U.S. Public Health Service (EYO14619)
National Eye Institute (R01EY014619)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Subterranean biodiversity and taxonomy
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: regressive evolution, Astyanax mexicanus, cavefish, eye loss, pigmentation loss, cave adaptation, parallel evolution, developmental genetics
MeSH terms: Animals, Darkness, Biological Evolution, Eye, Fishes, Skin Pigmentation

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Regressive Evolution in Astyanax Cavefish

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