The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Complement and Its Receptors: New Insights into Human Disease
Open accessAbstract
Although new activation and regulatory mechanisms are still being identified, the basic architecture of the complement system has been known for decades. Two major roles of complement are to control certain bacterial infections and to promote clearance of apoptotic cells. In addition, although inappropriate complement activation has long been proposed to cause tissue damage in human inflammatory and autoimmune diseases, whether this is indeed true has been uncertain. However, recent studies in humans, especially those using newly available biological therapeutics, have now clearly demonstrated the pathophysiologic importance of the complement system in several rare diseases. Beyond these conditions, recent genetic studies have strongly supported an injurious role for complement in a wide array of human inflammatory, degenerative, and autoimmune diseases. This review includes an overview of complement activation, regulatory, and effector mechanisms. It then focuses on new understandings gained from genetic studies, ex vivo analyses, therapeutic trials, and animal models as well as on new research opportunities.
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“Additional inducers of low-grade inflammation are nutrients and metabolites acting as DAMPs (e.g., free fatty acids, oxidized lipoproteins) and commensal bacteria representing a source of PAMPs [sometimes also described with the more global term microbe-associated molecular patterns (MAMPs), as they are not necessarily pathogenic] (189, 240, 244, 295, 329, 347).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [240]
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Cites
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 3×
“Additionally, the recently recognized roles of complement in homeostasis point to several nontraditional functions that bridge immunity and developmental biology (12).”
BackgroundInfluentialEvolving concepts of rheumatoid arthritis
Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,653
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
The Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,711
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
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Generation of C5a in the absence of C3: a new complement activation pathway
Huber-Lang, M. S., Sarma, J. V., Zetoune, F. S., Rittirsch, D., Neff, T. A., McGuire, S. R., Lambris, J. D., Warner, R. L., Flierl, M. A., Hoesel, L. M., et al. (2006) · Nature Medicine · doi:10.1038/nm1419 · Cited by 976
MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM
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“On red blood cells, the absence of DAF allows alternative pathway–initiated complement activation by C3 and C5 convertases; the absence of CD59 allows activated C5 to proceed to form the MAC, resulting in intravascular hemolysis (102, 103).”
BackgroundModulation of the antitumor immune response by complement
Markiewski, M. M., DeAngelis, R. A., Benencia, F., Ricklin-Lichtsteiner, S. K., Koutoulaki, A., Gerard, C. J., Coukos, G., & Lambris, J. D. (2008) · Nature Immunology · doi:10.1038/ni.1655 · Cited by 770
Molecular Intercommunication between the Complement and Coagulation Systems
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Cited by
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift
Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799
Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C.-A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.018 · Cited by 697
Klebsiella pneumoniae infection biology: living to counteract host defences
Bengoechea, J. A., & Sá‐Pessoa, J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy043 · Cited by 605
The role of the complement system in cancer
Afshar‐Kharghan, V. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90962 · Cited by 565
Metadata
- Authors
- Holers, V. M.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Holers, V. Michael
- ORCID
- Holers, V. Michael
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 433-459
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2163243965
- Cited by
- 430
- References
- 152
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 33 · 2023: 27 · 2022: 39 · 2021: 48 · 2020: 46 · 2019: 42 · 2018: 34 · 2017: 40 · 2016: 36 · 2015: 27 · 2014: 10
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lupus Research Alliance
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI105717)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR051749)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- complement system, complement receptors, complement activation, complement regulation, efferocytosis, bacterial infection, inflammatory diseases, autoimmune disease, degenerative diseases, rare diseases, genetic research, complement therapeutics, tissue damage
- MeSH terms
- Animals, Carrier Proteins, Complement System Proteins, Complement Activation, Disease Models, Animal, Disease Susceptibility, Humans, Protein Binding, Receptors, Complement, Signal Transduction, Genetic Predisposition to Disease
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