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Cited by 65Iron Metabolism and DisordersErythropoietin and Anemia TreatmentAutoimmune and Inflammatory Disorders Research

Immune Mechanisms in Inflammatory Anemia

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Canny, Susan P., Orozco, Susana L., Thulin, Natalie K., Hamerman, Jessica A.·2023·Annual Review of Immunology
DOI 10.1146/annurev-immunol-101320-125839PMC PMC10367595
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Abstract

Maintaining the correct number of healthy red blood cells (RBCs) is critical for proper oxygenation of tissues throughout the body. Therefore, RBC homeostasis is a tightly controlled balance between RBC production and RBC clearance, through the processes of erythropoiesis and macrophage hemophagocytosis, respectively. However, during the inflammation associated with infectious, autoimmune, or inflammatory diseases this homeostatic process is often dysregulated, leading to acute or chronic anemia. In each disease setting, multiple mechanisms typically contribute to the development of inflammatory anemia, impinging on both sides of the RBC production and RBC clearance equation. These mechanisms include both direct and indirect effects of inflammatory cytokines and innate sensing. Here, we focus on common innate and adaptive immune mechanisms that contribute to inflammatory anemias using examples from several diseases, including hemophagocytic lymphohistiocytosis/macrophage activation syndrome, severe malarial anemia during Plasmodium infection, and systemic lupus erythematosus, among others.

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  • Reduced RBC levels impair oxygen transport, leading to diminished physical capabilities, impaired feeding behaviors, increased organ damage, and compromised immune systems.

    “Reduced RBC levels impair oxygen transport, leading to diminished physical capabilities, impaired feeding behaviors, increased organ damage, and compromised immune systems (Canny et al., 2023; Ekiz et al., 2005).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Canny et al., 2023

    The Abstract says healthy RBC numbers are critical for tissue oxygenation, and the Overview of Red Blood Cell Homeostasis defines anemia as insufficient healthy RBCs. Our copy does not link reduced RBC levels to the claimed changes in physical capability, feeding behavior, organ damage, or immune function. No page numbers are provided for these passages. (LLM, conf=0.86)

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References 144 · Cited by 65

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Authors
Canny, S. P., Orozco, S. L., Thulin, N. K., & Hamerman, J. A.
Affiliations
  • University of Washington (US)
  • Benaroya Research Institute (US)
Corresponding author
  • Canny, Susan P.
  • Orozco, Susana L.
  • Thulin, Natalie K.
ORCID
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2023-04-26
Volume
41
Issue
1
Pages
405-429
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev-immunol-101320-125839
PMC
PMC10367595
OpenAlex
W4319335644
Cited by
65
References
144
Citations by year
2026: 20 · 2025: 28 · 2024: 15 · 2023: 2
FWCI
3.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Annual Review of Immunology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Lupus Research Alliance
  • National Research Foundation
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (F32HL156516, F32HL154700)
  • National Institute of Allergy and Infectious Diseases (R01AI150178, F31AI172078, R21AI154841, T32AI106677)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR076242, T32AR007108)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007233)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords
inflammatory anemia, erythropoiesis, inflammatory cytokines, innate immune recognition, hemophagocytic lymphohistiocytosis, macrophage activation syndrome, severe malarial anemia, malaria, systemic lupus erythematosus, autoimmune disease, infectious diseases
MeSH terms
Anemia, Animals, Erythrocytes, Erythropoiesis, Humans, Macrophages, Malaria

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