The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Mechanisms of Acid Resistance in Escherichia coli
Abstract
Adaptation to acid stress is an important factor in the transmission of intestinal microbes. The enterobacterium Escherichia coli uses a range of physiological, metabolic, and proton-consuming acid resistance mechanisms in order to survive acid stresses as low as pH 2.0. The physiological adaptations include membrane modifications and outer membrane porins to reduce proton influx and periplasmic and cytoplasmic chaperones to manage the effects of acid damage. The metabolic acid resistance systems couple proton efflux to energy generation via select components of the electron transport chain, including cytochrome bo oxidase, NADH dehydrogenase I, NADH dehydrogenase II, and succinate dehydrogenase. Under anaerobic conditions the formate hydrogen lyase complex catalyzes conversion of cytoplasmic protons to hydrogen gas. Finally, each major proton-consuming acid resistance system has a pyridoxal-5′-phosphate-dependent amino acid decarboxylase that catalyzes proton-dependent decarboxylation of a substrate amino acid to product and CO 2, and an inner membrane antiporter that exchanges external substrate for internal product.
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The PyMOL Molecular Graphics System
DeLano, W. L. (2002) · Medical Entomology and Zoology · Cited by 18,147
Crystal structures explain functional properties of two E. coli porins
Cowan, S. W., Schirmer, T., Rummel, G., Steiert, M., Ghosh, R., Pauptit, R. A., Jansonius, J. N., & Rosenbusch, J. P. (1992) · Nature · doi:10.1038/358727a0 · Cited by 1,520
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/415287a · Cited by 1,446
Molecular aspects of bacterial pH sensing and homeostasis
Krulwich, T. A., Sachs, G., & Padan, E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2549 · Cited by 1,042
Escherichia coli acid resistance: tales of an amateur acidophile
Foster, J. W. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1021 · Cited by 966
Architecture of succinate dehydrogenase and reactive oxygen species generation
Yankovskaya, V., Horsefield, R., Törnroth, S., Luna-Chavez, C., Miyoshi, H., Léger, C., Byrne, B., Cecchini, G., & Iwata, S. (2003) · Science · doi:10.1126/science.1079605 · Cited by 927
Gating the Selectivity Filter in ClC Chloride Channels
Dutzler, R., Campbell, E. B., & MacKinnon, R. (2003) · Science · doi:10.1126/science.1082708 · Cited by 727
Control of Acid Resistance in Escherichia coli
Castanie-Cornet, M.-P., Penfound, T. A., Smith, D., Elliott, J. F., & Foster, J. W. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.11.3525-3535.1999 · Cited by 623
The architecture of respiratory complex I
Efremov, R. G., Baradaran, R., & Sazanov, L. A. (2010) · Nature · doi:10.1038/nature09066 · Cited by 617
Mechanisms of acid resistance in enterohemorrhagic Escherichia coli
Lin, J., Smith, M. P., Chapin, K. C., Baik, H. S., Bennett, G. N., & Foster, J. W. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.9.3094-3100.1996 · Cited by 574
Cited by
DegP functions as a critical protease for bacterial acid resistance
Fu, X., Wang, Y., Shao, H., Ma, J., Song, X., Zhang, M., & Chang, Z. (2018) · The FEBS Journal · doi:10.1111/febs.14627 · Cited by 35
Metadata
- Authors
- Kanjee, U., & Houry, W. A.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2013-09-08
- Volume
- 67
- Issue
- 1
- Pages
- 65-81
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2152434411
- Cited by
- 339
- References
- 81
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
