RNA Protein Interaction in Neurons
Open accessAbstract
Neurons have their own systems for regulating RNA. Several multigene families encode RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease antigen NOVA. New technologies have emerged in recent years to assess the function of these proteins in vivo, and the answers are yielding insights into how and why neurons may regulate RNA in special ways—to increase cellular complexity, to localize messenger RNA (mRNA) spatially, and to regulate their expression in response to synaptic stimuli. The functions of such restricted neuronal proteins are likely to be complemented by more widely expressed RNABPs that may themselves have developed specialized functions in neurons, including Argonaute/microRNAs (miRNAs). Here we review what is known about such RNABPs and explore the potential biologic and neurologic significance of neuronal RNA regulatory systems.
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The mammalian nervous system makes extensive use of splicing regulation to generate specialized protein isoforms that affect all aspects of neuronal development and function.
“the mammalian nervous system makes extensive use of splicing regulation to generate specialized protein isoforms that affect all aspects of neuronal development and function1–4.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [4]
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References 218 · Cited by 181
- Authors
- Darnell, R. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Darnell, Robert B.
- ORCID
- Darnell, Robert B.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2013-07-08
- Volume
- 36
- Issue
- 1
- Pages
- 243-270
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3889695
- OpenAlex
- W2096911942
- Cited by
- 181
- References
- 218
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 10 · 2018: 16 · 2017: 18 · 2016: 22 · 2015: 15 · 2014: 22 · 2013: 3
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Simons Foundation
- Emerald Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS081706, R01 NS34389, NS081706, R01NS034389)
- National Center for Research Resources (UL1RR024143)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- RNA-binding proteins, neurons, RNA regulation, ELAV, NeuN, nova, mRNA localization, Argonaute proteins, microRNA, neuronal gene expression
- MeSH terms
- Animals, Brain, Neurons, RNA, Messenger, RNA-Binding Proteins
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