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Neuronal and Vascular Interactions
Open accessAbstract
The brain, which represents 2% of body mass but consumes 20% of body energy at rest, has a limited capacity to store energy and is therefore highly dependent on oxygen and glucose supply from the blood stream. Normal functioning of neural circuits thus relies on adequate matching between metabolic needs and blood supply. Moreover, not only does the brain need to be densely vascularized, it also requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for synaptic transmission and neuronal function. In this review, we focus on three major factors that ensure optimal brain perfusion and function: the patterning of vascular networks to efficiently deliver blood and nutrients, the function of the blood-brain barrier to maintain brain homeostasis, and the regulation of cerebral blood flow to adequately couple energy supply to neural function.
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“which is likely a reflection of the maturation of vascular structures during late-stage development or activity-dependent growth and/or remodeling of vascular structures”
From Molecular and spatial signatures of mouse brain aging at single-cell resolution (2023) · cites this paper as [8]
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“Neuronal activity during embryonic development and in the early days of postnatal development generates a relatively hypoxic environment that is permissive for vascular development and maturation (22).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [22]
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“Both cerebral angiogenesis and BBB formation require precise cues from various growth factors, guidance molecules and other factors such as microRNA, as well as fine tuning of intracellular signaling pathways and gene expression (22, 628, 682, 689).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [22]
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“and neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions (22, 475, 596, 628).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [22]
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“To date, evidence obtained from developmental studies clearly depicts an orchestrated interaction between the neural and vascular systems for proper establishment of the BBB and wiring of the brain (22, 93, 158).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [22]
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References 154 · Cited by 256
Research works printed but not linked: 3
- Cipolla MJ, 2009, The Cerebral Circulation, 3
- Grant GA, 1998, News Physiol. Sci., 13, 287
- Martin P, 1989, Int. J. Dev. Biol., 33, 379
Metadata
- Authors
- Andreone, B. J., Lacoste, B., & Gu, C.
- Affiliations
- Harvard University (US)
- Corresponding author
- Gu, Chenghua
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2015-07-08
- Volume
- 38
- Issue
- 1
- Pages
- 25-46
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC5729758
- OpenAlex
- W2122372853
- Cited by
- 256
- References
- 154
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 21 · 2023: 35 · 2022: 43 · 2021: 35 · 2020: 24 · 2019: 22 · 2018: 16 · 2017: 18 · 2016: 6 · 2015: 3
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS064583, DP1NS092473)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- cerebral perfusion, cerebral autoregulation, blood-brain barrier, brain vascularization, brain energy metabolism, brain homeostasis, neurovascular coupling
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Homeostasis, Humans, Neurons
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