The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer
Open accessAbstract
Organic anion transporting polypeptides (OATPs) are members of the SLCO gene superfamily of proteins. The 11 human OATPs are classified into 6 families and subfamilies on the basis of their amino acid sequence similarities. OATPs are expressed in several epithelial tissues throughout the body and transport mainly amphipathic molecules with molecular weights of more than 300 kDa. Members of the OATP1 and OATP2 families are functionally the best-characterized OATPs. Among these are the multispecific OATP1A2, OATP1B1, OATP1B3, and OATP2B1. They transport various endo- and xenobiotics, including hormones and their conjugates as well as numerous drugs such as several anticancer agents. Recent reports demonstrate that some OATPs are up- or downregulated in several cancers and that OATP expression might affect cancer development. On the basis of the findings summarized in this review, we propose that OATPs could be valuable targets for anticancer therapy.
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Roberts, L. M., Woodford, K., Zhou, M., Black, D. S., Haggerty, J. E., Tate, E. H., Grindstaff, K. K., Mengesha, W., Raman, C., & Zerangue, N. (2008) · Endocrinology · doi:10.1210/en.2008-0378 · Cited by 320
Feng, B., Xu, J. J., Bi, Y.-A., Mireles, R., Davidson, R., Duignan, D. B., Campbell, S., Kostrubsky, V. E., Dunn, M. C., Smith, A. R., et al. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp033 · Cited by 80
Cited by
Hladky, S. B., & Barrand, M. A. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0113-6 · Cited by 206
The Placental Barrier: the Gate and the Fate in Drug Distribution
Tetro, N., Moushaev, S., Rubinchik-Stern, M., & Eyal, S. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2286-0 · Cited by 145
A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila
Okamoto, N., Viswanatha, R., Bittar, R., Li, Z., Haga-Yamanaka, S., Perrimon, N., & Yamanaka, N. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.012 · Cited by 144
Boyer, J. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00519.x · Cited by 124
Aregger, M., Lawson, K. A., Billmann, M., Costanzo, M., Tong, A. H. Y., Chan, K., Rahman, M., Brown, K. R., Ross, C., Usaj, M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0211-z · Cited by 115
Metadata
- Authors
- Obaidat, A., Roth, M., & Hagenbuch, B.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2012-02-10
- Volume
- 52
- Issue
- 1
- Pages
- 135-151
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2145006425
- Cited by
- 295
- References
- 2
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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