The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments
Open accessAbstract
Various organic reactions, including important synthetic reactions involving C–C, C–N, and C–O bond formation as well as reactions of biomolecules, are accelerated when the reagents are present in sprayed or levitated microdroplets or in thin films. The reaction rates increase by orders of magnitude with decreasing droplet size or film thickness. The effect is associated with reactions at the solution–air interface. A key factor is partial solvation of the reagents at the interface, which reduces the critical energy for reaction. This phenomenon is of intrinsic interest and potentially of practical value as a simple, rapid method of performing small-scale synthesis.
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Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
Takáts, Z., Wiseman, J. M., Gologan, B., & Cooks, R. G. (2004) · Science · doi:10.1126/science.1104404 · Cited by 3,369
Self-citationThe E Factor: fifteen years on
Sheldon, R. A. (2007) · Green Chemistry · doi:10.1039/b713736m · Cited by 1,715
“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
Narayan, S., Muldoon, J., Finn, M. G., Fokin, V. V., Kolb, H. C., & Sharpless, K. B. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462883 · Cited by 1,691
Dole, M., Mack, L. L., Hines, R. L., Mobley, R. C., Ferguson, L., & Alice, M. B. (1968) · The Journal of Chemical Physics · doi:10.1063/1.1670391 · Cited by 1,606
Scriven, L. E., & Sternling, C. V. (1960) · Nature · doi:10.1038/187186a0 · Cited by 1,393
Anomalously low dielectric constant of confined water
Fumagalli, L., Esfandiar, A., Fabregas, R., Hu, S., Ares, P., Janardanan, A., Yang, Q., Radha, B., Taniguchi, T., Watanabe, K., et al. (2018) · Science · doi:10.1126/science.aat4191 · Cited by 1,067
Interfacial turbulence: Hydrodynamic instability and the marangoni effect
Sternling, C. V., & Scriven, L. E. (1959) · AIChE Journal · doi:10.1002/aic.690050421 · Cited by 1,038
A two-dimensional quadrupole ion trap mass spectrometer
Schwartz, J. C., Senko, M. W., & Syka, J. E. P. (2002) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(02)00384-7 · Cited by 800
Mass spectrometry: principles and applications
(2008) · Choice Reviews Online · doi:10.5860/choice.45-4389 · Cited by 779
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Water structure and electric fields at the interface of oil droplets
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Metadata
- Authors
- Wei, Z., Li, Y., Cooks, R. G., & Yan, X.
- Affiliations
- Purdue University West Lafayette (US)
- Texas A&M University (US)
- Corresponding author
- Yan, Xin
- Venue
- Annual Review of Physical Chemistry
- Publisher
- Annual Reviews
- Published
- 2020-04-20
- Volume
- 71
- Issue
- 1
- Pages
- 31-51
- ISSN
- 0066-426X (ISSN-L)
- 1545-1593
- OpenAlex
- W3017097444
- Cited by
- 631
- References
- 122
- Citations by year
- 2026: 117 · 2025: 142 · 2024: 123 · 2023: 91 · 2022: 73 · 2021: 62 · 2020: 23
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1905087)
- Defense Advanced Research Projects Agency (1905087, W911NF-16-2-0020)
- Advanced Research Projects Agency
- Topics
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Innovative Microfluidic and Catalytic Techniques Innovation
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Physical Sciences › Engineering › Computational Mechanics › Fluid Dynamics and Heat Transfer
- Keywords
- microdroplets, reaction kinetics, air/solution interface, levitated droplets, thin films, C–C bond formation, C–N bond formation, C–O bond formation, small-scale synthesis, reaction rate enhancement
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