The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Sodium Channel β Subunits: Emerging Targets in Channelopathies
Open accessAbstract
Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric complexes of α and β subunits. Although β subunits were originally termed auxiliary, we now know that they are multifunctional signaling molecules that play roles in both excitable and nonexcitable cell types and with or without the pore-forming α subunit present. β subunits function in VGSC and potassium channel modulation, cell adhesion, and gene regulation, with particularly important roles in brain development. Mutations in the genes encoding β subunits are linked to a number of diseases, including epilepsy, sudden death syndromes like SUDEP and SIDS, and cardiac arrhythmia. Although VGSC β subunit–specific drugs have not yet been developed, this protein family is an emerging therapeutic target.
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Cites
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Self-citationVoltage-gated sodium channels and metastatic disease
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Cited by
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Structure of the human voltage-gated sodium channel Na v 1.4 in complex with β1
Pan, X., Li, Z., Zhou, Q., Shen, H., Wu, K., Huang, X., Chen, J., Zhang, J., Zhu, X., Lei, J., et al. (2018) · Science · doi:10.1126/science.aau2486 · Cited by 417
Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies
Oyrer, J., Maljevic, S., Scheffer, I. E., Berkovic, S. F., Petrou, S., & Reid, C. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014456 · Cited by 315
Structure of the Nav1.4-β1 Complex from Electric Eel
Yan, Z., Zhou, Q., Wang, L., Wu, J., Zhao, Y., Huang, G., Peng, W., Shen, H., Lei, J., & Yan, N. (2017) · Cell · doi:10.1016/j.cell.2017.06.039 · Cited by 317
Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels
Catterall, W. A., Lenaeus, M. J., & Gamal El-Din, T. M. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021757 · Cited by 281
Metadata
- Authors
- O'Malley, H. A., & Isom, L. L.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2015-02-10
- Volume
- 77
- Issue
- 1
- Pages
- 481-504
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2133923664
- Cited by
- 236
- References
- 12
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
