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Cited by 248Liver physiology and pathologyTissue Engineering and Regenerative MedicineOrgan Transplantation Techniques and Outcomes

Cellular Homeostasis and Repair in the Mammalian Liver

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Stanger, Ben Z.·2015·Annual Review of Physiology
DOI 10.1146/annurev-physiol-021113-170255PMC PMC5830102
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Abstract

The mammalian liver is one of the most regenerative tissues in the body, capable of fully recovering mass and function after a variety of injuries. This factor alone makes the liver unusual among mammalian tissues, but even more atypical is the widely held notion that the method of repair depends on the manner of injury. Specifically, the liver is believed to regenerate via replication of existing cells under certain conditions and via differentiation from specialized cells—so-called facultative stem cells—under others. Nevertheless, despite the liver's dramatic and unique regenerative response, the cellular and molecular features of liver homeostasis and regeneration are only now starting to come into relief. This review provides an overview of normal liver function and development and focuses on the evidence for and against various models of liver homeostasis and regeneration.

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Authors
Stanger, B. Z.
Affiliations
Abramson Cancer Center (US)
Corresponding author
Stanger, Ben Z.
ORCID
Stanger, Ben Z.
Venue
Annual Review of Physiology
Publisher
Annual Reviews
Published
2015-02-10
Volume
77
Issue
1
Pages
179-200
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
DOI
10.1146/annurev-physiol-021113-170255
PMC
PMC5830102
OpenAlex
W2020738127
Cited by
248
References
124
Citations by year
2026: 5 · 2025: 28 · 2024: 40 · 2023: 33 · 2022: 24 · 2021: 27 · 2020: 28 · 2019: 15 · 2018: 20 · 2017: 8 · 2016: 13 · 2015: 7
FWCI
2.29
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083355)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
liver regeneration, liver homeostasis, hepatocyte proliferation, liver development, liver injury repair, hepatocyte differentiation, tissue regeneration
MeSH terms
Animals, Cell Differentiation, Homeostasis, Humans, Liver, Liver Diseases, Liver Regeneration, Stem Cells, Hepatocytes, Cell Proliferation

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