The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mass Spectrometry–Based Biomarker Discovery: Toward a Global Proteome Index of Individuality
Open accessAbstract
Biomarker discovery and proteomics have become synonymous with mass spectrometry in recent years. Although this conflation is an injustice to the many essential biomolecular techniques widely used in biomarker-discovery platforms, it underscores the power and potential of contemporary mass spectrometry. Numerous novel and powerful technologies have been developed around mass spectrometry, proteomics, and biomarker discovery over the past 20 years to globally study complex proteomes (e.g., plasma). However, very few large-scale longitudinal studies have been carried out using these platforms to establish the analytical variability relative to true biological variability. The purpose of this review is not to cover exhaustively the applications of mass spectrometry to biomarker discovery, but rather to discuss the analytical methods and strategies that have been developed for mass spectrometry–based biomarker-discovery platforms and to place them in the context of the many challenges and opportunities yet to be addressed.
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Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Anderson, N. L., & Anderson, N. G. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r200007-mcp200 · Cited by 4,414
Cited by
Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers
Chikkaveeraiah, B. V., Bhirde, A. A., Morgan, N. Y., Eden, H. S., & Chen, X. (2012) · ACS Nano · doi:10.1021/nn3023969 · Cited by 719
Intact stable isotope labeled plasma proteins from the SILAC-labeled HepG2 secretome
Mangrum, J. B., Martin, E. J., Brophy, D. F., & Hawkridge, A. M. (2015) · PROTEOMICS · doi:10.1002/pmic.201400369 · Cited by 8
Self-citation
Metadata
- Authors
- Hawkridge, A. M., & Muddiman, D. C.
- Venue
- Annual Review of Analytical Chemistry
- Publisher
- Annual Reviews
- Published
- 2009-07-19
- Volume
- 2
- Issue
- 1
- Pages
- 265-277
- ISSN
- 1936-1327 (ISSN-L)
- 1936-1335
- OpenAlex
- W2147562834
- Cited by
- 160
- References
- 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Hawkridge, A. M., & Muddiman, D. C. (2009). Mass Spectrometry–Based Biomarker Discovery: Toward a Global Proteome Index of Individuality. Annual Review of Analytical Chemistry. https://doi.org/10.1146/annurev.anchem.1.031207.112942
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