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DNA POLYMERASE III HOLOENZYME: Structure and Function of a Chromosomal Replicating Machine
Abstract
DNA polymerase III holoenzyme contains two DNA polymerases embedded in a particle with 9 other subunits. This multi subunit DNA polymerase is the Escherichia coli chromosomal replicase, and it has several special features that distinguish it as a replicating machine. For example, one of its subunits is a circular protein that slides along DNA while clamping the rest of the machinery to the template. Other subunits act together as a matchmaker to assemble the ring onto DNA. Overall, E. coli DNA polymerase III holoenzyme is very similar in both structure and function to the chromosomal replicases of eukaryotes, from yeast all the way up to humans. This review summarizes our present knowledge about the function of the 10 subunits of this replicating machine and how they coordinate their actions for smooth duplication of chromosomes.
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Cited by
Growth of the Stress-Bearing and Shape-Maintaining Murein Sacculus of Escherichia coli
Höltje, J.-V. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.181-203.1998 · Cited by 1,129
Replication and Control of Circular Bacterial Plasmids
del Solar, G., Giraldo, R., Ruiz-Echevarría, M. J., Espinosa, M., & Díaz-Orejas, R. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.434-464.1998 · Cited by 938
Kogoma, T. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.2.212-238.1997 · Cited by 532
Statistical physics of self-replication
England, J. L. (2013) · The Journal of Chemical Physics · doi:10.1063/1.4818538 · Cited by 449
polι, a remarkably error-prone human DNA polymerase
Tissier, A., McDonald, J. P., Frank, E. G., & Woodgate, R. (2000) · Genes & Development · doi:10.1101/gad.14.13.1642 · Cited by 315
Metadata
- Authors
- Kelman, Z., & O'Donnell, M.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1995-06
- Volume
- 64
- Issue
- 1
- Pages
- 171-200
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2111745935
- Cited by
- 442
- References
- 0
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DNA POLYMERASE III HOLOENZYME: Structure and Function of a Chromosomal Replicating Machine. https://app.cochat.ai/papers/10.1146/annurev.bi.64.070195.001131
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- Kelman, Z., & O'Donnell, M. (1995). DNA POLYMERASE III HOLOENZYME: Structure and Function of a Chromosomal Replicating Machine. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.bi.64.070195.001131
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
