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EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS
Abstract
The current status of the biochemistry of phospholipid biosynthesis is presented. The review focuses on the identification and characterization of molecular tools such as purified enzymes and cloned genes and cDNAs for those enzymes. The enzymes discussed are those involved in the biosynthesis of the major phospholipid classes, namely, phosphatidate, phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, sphingomyelin, phosphatidylinositol and its phosphorylated derivatives, and cardiolipin. The review centers on the pathways in mammals and yeast. Novel genetic approaches used to delineate pathways and clone cDNAs are discussed. The regulatory roles played by some of the enzymes involved in controlling the biosynthetic pathways are presented.
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Citations
Cited by
Cholesterol interactions with phospholipids in membranes
Ohvo-Rekilä, H. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00020-0 · Cited by 1,003
Enzymes of triacylglycerol synthesis and their regulation
Coleman, R. (2004) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00051-1 · Cited by 965
van Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P., & van Meer, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81370-7 · Cited by 855
Schneiter, R., Brügger, B., Sandhoff, R., Zellnig, G., Leber, A., Lampl, M., Athenstaedt, K., Hrastnik, C., Eder, S., Daum, G., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.741 · Cited by 493
Phosphatidic acid, a key intermediate in lipid metabolism
Athenstaedt, K., & Daum, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00822.x · Cited by 403
Metadata
- Authors
- Kent, C.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1995-06
- Volume
- 64
- Issue
- 1
- Pages
- 315-343
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2141810718
- Cited by
- 381
- References
- 0
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kent, C. (1995). EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.bi.64.070195.001531
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