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DNA TOPOISOMERASES
Abstract
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes. Newly discovered members and recent biochemical and structural results are reviewed, and mechanistic implications of these results are summarized. The primary cellular functions of these enzymes, including their roles in replication, transcription, chromosome condensation, and the maintenance of genome stability, are then discussed. The review ends with a summary of the regulation of the cellular levels of these enzymes and a discussion of their association with other cellular proteins.
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Citations
Cited by
DNA Topoisomerases: Structure, Function, and Mechanism
Champoux, J. J. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.369 · Cited by 2,743
The mitochondrial genome: structure, transcription, translation and replication
Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
The role of the unfolded protein response in tumour development: friend or foe?
Ma, Y., & Hendershot, L. M. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1505 · Cited by 710
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Greaves, M. F., & Wiemels, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1164 · Cited by 699
Metadata
- Authors
- Wang, J. C.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1996-06
- Volume
- 65
- Issue
- 1
- Pages
- 635-692
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W4236530034
- Cited by
- 1,832
- References
- 0
- FWCI
- 36.12
- Type
- journal article
- Language
- en
- Open access
- closed
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