The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Initiation of Base Excision Repair: Glycosylase Mechanisms and Structures
Abstract
▪ Abstract The base excision repair pathway is an organism's primary defense against mutations induced by oxidative, alkylating, and other DNA-damaging agents. This pathway is initiated by DNA glycosylases that excise the damaged base by cleavage of the glycosidic bond between the base and the DNA sugar-phosphate backbone. A subset of glycosylases has an associated apurinic/apyrimidinic (AP) lyase activity that further processes the AP site to generate cleavage of the DNA phosphate backbone. Chemical mechanisms that are supported by biochemical and structural data have been proposed for several glycosylases and glycosylase/AP lyases. This review focuses on the chemical mechanisms of catalysis in the context of recent structural information, with emphasis on the catalytic residues and the active site conformations of several cocrystal structures of glycosylases with their substrate DNAs. Common structural motifs for DNA binding and damage specificity as well as conservation of acidic residues and amino groups for catalysis are discussed.
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Cites
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
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Mutagenesis by 8-oxoguanine: an enemy within
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Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair
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The Relative Cytotoxicity of (6-4) Photoproducts and Cyclobutane Dimers in Mammalian Cells
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Cited by
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
ROS1, a Repressor of Transcriptional Gene Silencing in Arabidopsis, Encodes a DNA Glycosylase/Lyase
Gong, Z., Morales-Ruiz, T., Ariza, R. R., Roldán-Arjona, T., David, L., & Zhu, J.-K. (2002) · Cell · doi:10.1016/s0092-8674(02)01133-9 · Cited by 772
Active DNA Demethylation Mediated by DNA Glycosylases
Zhu, J.-K. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134205 · Cited by 745
How nucleotide excision repair protects against cancer
Friedberg, E. C. (2001) · Nature Reviews Cancer · doi:10.1038/35094000 · Cited by 730
Vidal, A. E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6530 · Cited by 458
Metadata
- Authors
- McCullough, A. K., Dodson, M. L., & Lloyd, R. S.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1999-06
- Volume
- 68
- Issue
- 1
- Pages
- 255-285
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2158742644
- Cited by
- 380
- References
- 5
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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