The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structural Mechanism of Muscle Contraction
Abstract
▪ Abstract X-ray crystallography shows the myosin cross-bridge to exist in two conformations, the beginning and end of the “power stroke.” A long lever-arm undergoes a 60° to 70° rotation between the two states. This rotation is coupled with changes in the active site (OPEN to CLOSED) and phosphate release. Actin binding mediates the transition from CLOSED to OPEN. Kinetics shows that the binding of myosin to actin is a two-step process which affects ATP and ADP affinity. The structural basis of these effects is not explained by the presently known conformers of myosin. Therefore, other states of the myosin cross-bridge must exist. Moreover, cryoelectronmicroscopy has revealed other angles of the cross-bridge lever arm induced by ADP binding. These structural states are presently being characterized by site-directed mutagenesis coupled with kinetic analysis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
CUDA, G., FANANAPAZIR, L., EPSTEIN, N. D., & SELLERS, J. R. (1997) · Journal of Muscle Research & Cell Motility · doi:10.1023/a:1018613907574 · Cited by 137
Cited by
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Mechanism of Blebbistatin Inhibition of Myosin II
Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., & Sellers, J. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405319200 · Cited by 1,019
Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization
Forkey, J. N., Quinlan, M. E., Alexander Shaw, M., Corrie, J. E. T., & Goldman, Y. E. (2003) · Nature · doi:10.1038/nature01529 · Cited by 455
The Molecular Mechanism of Muscle Contraction
Geeves, M. A., & Holmes, K. C. (2005) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)71005-0 · Cited by 398
Self-citationCryo-EM structure of the human cardiac myosin filament
Dutta, D., Nguyen, V., Campbell, K. S., Padrón, R., & Craig, R. (2023) · Nature · doi:10.1038/s41586-023-06691-4 · Cited by 164
Metadata
- Authors
- Geeves, M. A., & Holmes, K. C.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1999-06
- Volume
- 68
- Issue
- 1
- Pages
- 687-728
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2154535641
- Cited by
- 781
- References
- 1
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structural Mechanism of Muscle Contraction. https://app.cochat.ai/papers/10.1146/annurev.biochem.68.1.687
- The paper
- Geeves, M. A., & Holmes, K. C. (1999). Structural Mechanism of Muscle Contraction. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.68.1.687
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
