The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ribozyme Structures and Mechanisms
Abstract
▪ Abstract The past few years have seen exciting advances in understanding the structure and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed insight into the folds of RNA molecules. Models of other biologically important RNAs have been constructed based on structural, phylogenetic, and biochemical data. However, many questions regarding the catalytic mechanisms of ribozymes remain. This review compares the structures and possible catalytic mechanisms of four small self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro–selected lead-dependent ribozymes. The organization of these small catalysts is contrasted to that of larger ribozymes, such as the group I intron.
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Cites
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
A general two-metal-ion mechanism for catalytic RNA
Steitz, T. A., & Steitz, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6498 · Cited by 1,171
Peptide bond formation by in vitro selected ribozymes
Zhang, B., & Cech, T. R. (1997) · Nature · doi:10.1038/36375 · Cited by 299
Cited by
Asymmetric Catalysis by Chiral Hydrogen‐Bond Donors
Taylor, M. S., & Jacobsen, E. N. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503132 · Cited by 1,906
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Control of gene expression by a natural metabolite-responsive ribozyme
Winkler, W. C., Nahvi, A., Roth, A., Collins, J. A., & Breaker, R. R. (2004) · Nature · doi:10.1038/nature02362 · Cited by 951
Correlating Structural Dynamics and Function in Single Ribozyme Molecules
Zhuang, X., Kim, H., Pereira, M. J. B., Babcock, H. P., Walter, N. G., & Chu, S. (2002) · Science · doi:10.1126/science.1069013 · Cited by 512
The catalytic diversity of RNAs
Fedor, M. J., & Williamson, J. R. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1647 · Cited by 358
Metadata
- Authors
- Doherty, E. A., & Doudna, J. A.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2000-06
- Volume
- 69
- Issue
- 1
- Pages
- 597-615
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2104095017
- Cited by
- 217
- References
- 3
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Doherty, E. A., & Doudna, J. A. (2000). Ribozyme Structures and Mechanisms. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.69.1.597
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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