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The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes
Abstract
▪ Abstract Vitamin B 12 is a complex organometallic cofactor associated with three subfamilies of enzymes: the adenosylcobalamin-dependent isomerases, the methylcobalamin-dependent methyltransferases, and the dehalogenases. Different chemical aspects of the cofactor are exploited during catalysis by the isomerases and the methyltransferases. Thus, the cobalt-carbon bond ruptures homolytically in the isomerases, whereas it is cleaved heterolytically in the methyltransferases. The reaction mechanism of the dehalogenases, the most recently discovered class of B 12 enzymes, is poorly understood. Over the past decade our understanding of the reaction mechanisms of B 12 enzymes has been greatly enhanced by the availability of large amounts of enzyme that have afforded detailed structure-function studies, and these recent advances are the subject of this review.
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Cited by
Algae acquire vitamin B12 through a symbiotic relationship with bacteria
Croft, M. T., Lawrence, A. D., Raux-Deery, E., Warren, M. J., & Smith, A. G. (2005) · Nature · doi:10.1038/nature04056 · Cited by 1,536
Metal ions in biological catalysis: from enzyme databases to general principles
Andreini, C., Bertini, I., Cavallaro, G., Holliday, G. L., & Thornton, J. M. (2008) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-008-0404-5 · Cited by 1,150
Buckel, W., & Thauer, R. K. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.07.002 · Cited by 797
Brunk, E., & Rothlisberger, U. (2015) · Chemical Reviews · doi:10.1021/cr500628b · Cited by 494
Anaerobic Microbial Dehalogenation
Smidt, H., & de Vos, W. M. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123600 · Cited by 434
Metadata
- Authors
- Banerjee, R., & Ragsdale, S. W.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2003-06
- Volume
- 72
- Issue
- 1
- Pages
- 209-247
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2143351258
- Cited by
- 793
- References
- 0
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Banerjee, R., & Ragsdale, S. W. (2003). The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.72.121801.161828
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