The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
The Structural and Biochemical Foundations of Thiamin Biosynthesis
Open accessAbstract
Thiamin is synthesized by most prokaryotes and by eukaryotes such as yeast and plants. In all cases, the thiazole and pyrimidine moieties are synthesized in separate branches of the pathway and coupled to form thiamin phosphate. A final phosphorylation gives thiamin pyrophosphate, the active form of the cofactor. Over the past decade or so, biochemical and structural studies have elucidated most of the details of the thiamin biosynthetic pathway in bacteria. Formation of the thiazole requires six gene products, and formation of the pyrimidine requires two. In contrast, details of the thiamin biosynthetic pathway in yeast are only just beginning to emerge. Only one gene product is required for the biosynthesis of the thiazole and one for the biosynthesis of the pyrimidine. Thiamin can also be transported into the cell and can be salvaged through several routes. In addition, two thiamin degrading enzymes have been characterized, one of which is linked to a novel salvage pathway.
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Cites
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Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes
Magnúsdóttir, S., Ravcheev, D., de Crécy-Lagard, V., & Thiele, I. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00148 · Cited by 876
The Compositional and Evolutionary Logic of Metabolism
Braakman, R., & Smith, E. (2012) · Physical Biology · doi:10.1088/1478-3975/10/1/011001 · Cited by 158
Vödisch, M., Scherlach, K., Winkler, R., Hertweck, C., Braun, H.-P., Roth, M., Haas, H., Werner, E. R., Brakhage, A. A., & Kniemeyer, O. (2011) · Journal of Proteome Research · doi:10.1021/pr1012812 · Cited by 128
Paerl, R. W., Bertrand, E. M., Allen, A. E., Palenik, B., & Azam, F. (2015) · Limnology and Oceanography · doi:10.1002/lno.10009 · Cited by 80
Li, Y.-N., Luo, Y., Lu, Z.-M., Dong, Y.-L., Chai, L.-J., Shi, J.-S., Zhang, X.-J., & Xu, Z.-H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1142517 · Cited by 30
Metadata
- Authors
- Jurgenson, C. T., Begley, T. P., & Ealick, S. E.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 78
- Issue
- 1
- Pages
- 569-603
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2128474182
- Cited by
- 355
- References
- 93
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Jurgenson, C. T., Begley, T. P., & Ealick, S. E. (2009). The Structural and Biochemical Foundations of Thiamin Biosynthesis. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.78.072407.102340
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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