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Structural and Functional Insights into the Myosin Motor Mechanism
Abstract
The general structural features of the motor region of myosin superfamily members are now well established, as is a subset of the structural and kinetic transitions of the actin-myosin catalytic cycle. Not yet visualized are the structural rearrangements triggered by actin binding that are coupled to force generation and product release. In this review we describe the recent progress in understanding these missing components of the mechanism of chemomechanical transduction by myosin motors. These insights come from a combination of kinetic and single-molecule studies on multiple classes of myosins, with additional insights from contracting muscle fibers. These recent studies have explored the effects of intermediate and high loads on the kinetics of the actin-bound myosin state transitions. We also describe studies that delineate how some classes of myosin motors are adapted for processive movement on actin.
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Cites
Kinetic Mechanism and Regulation of Myosin VI
De La Cruz, E. M., Ostap, E. M., & Sweeney, H. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104136200 · Cited by 234
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Cited by
Targeting the sarcomere to correct muscle function
Hwang, P. M., & Sykes, B. D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4554 · Cited by 114
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
Doran, M. H., Rynkiewicz, M. J., Rasicci, D., Bodt, S. M. L., Barry, M. E., Bullitt, E., Yengo, C. M., Moore, J. R., & Lehman, W. (2023) · Journal of General Physiology · doi:10.1085/jgp.202213267 · Cited by 27
Metadata
- Authors
- Sweeney, H. L., & Houdusse, A.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2010-04
- Volume
- 39
- Issue
- 1
- Pages
- 539-557
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2149146343
- Cited by
- 422
- References
- 1
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sweeney, H. L., & Houdusse, A. (2010). Structural and Functional Insights into the Myosin Motor Mechanism. Annual Review of Biophysics. https://doi.org/10.1146/annurev.biophys.050708.133751
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