Ribozyme Structures and Mechanisms
Abstract
▪ Abstract The past few years have seen exciting advances in understanding the structure and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed insight into the folds of RNA molecules. Models of other biologically important RNAs have been constructed based on structural, phylogenetic, and biochemical data. However, many questions regarding the catalytic mechanisms of ribozymes remain. This review compares the structures and possible catalytic mechanisms of four small self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro–selected lead-dependent ribozymes. The organization of these small catalysts is contrasted to that of larger ribozymes, such as the group I intron.
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RNA enzymes can catalyze a wide variety of reactions, encompassing all types of transformations necessary for protocell activity.
“The RNA enzymes can catalyze a wide variety of reactions, encompassing all types of transformations necessary for the protocell activity (Doherty and Doudna, 2001; Lilley, 2003).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Doherty and Doudna, 2001
Cites
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684 · see citing works
Peptide bond formation by in vitro selected ribozymes
Zhang, B., & Cech, T. R. (1997) · Nature · doi:10.1038/36375 · Cited by 299 · see citing works
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Domagal-Goldman, S. D., Wright, K. E., Domagal-Goldman, S. D., Wright, K. E., Adamala, K., Arina de la Rubia, L., Bond, J., Dartnell, L. R., Goldman, A. D., Lynch, K., et al. (2016) · Astrobiology · doi:10.1089/ast.2015.1460 · Cited by 136 · see citing works
- Authors
- Doherty, E. A., & Doudna, J. A.
- Affiliations
- Yale University (US)
- Howard Hughes Medical Institute (US)
- ORCID
- Doudna, Jennifer A.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2001-06
- Volume
- 30
- Issue
- 1
- Pages
- 457-475
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W3024389904
- Cited by
- 195
- References
- 2
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 8 · 2012: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biophysics and Biomolecular Structure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- ribozymes, RNA structure, self-cleaving RNA, hammerhead ribozyme, hairpin ribozyme, hepatitis delta virus ribozyme, group I introns, RNA crystal structure, RNA folding
- MeSH terms
- Animals, Catalysis, Models, Chemical, RNA, RNA Splicing, Tetrahymena, RNA, Catalytic, Protein Structure, Secondary
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