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EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS
Abstract
Complex cellular events commonly depend on the activity of molecular “machines” that efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An essential and expanding subset of these assemblies comprises proteins of the ATPases associated with diverse cellular activities (AAA+) family. The defining feature of AAA+ proteins is a structurally conserved ATP-binding module that oligomerizes into active arrays. ATP binding and hydrolysis events at the interface of neighboring subunits drive conformational changes within the AAA+ assembly that direct translocation or remodeling of target substrates. In this review, we describe the critical features of the AAA+ domain, summarize our current knowledge of how this versatile element is incorporated into larger assemblies, and discuss specific adaptations of the AAA+ fold that allow complex molecular manipulations to be carried out for a highly diverse set of macromolecular targets.
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Citations
Cites
The interaction of Ras with GTPase‐activating proteins
Wittinghofer, A., Scheffzek, K., & Ahmadian, M. R. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00321-9 · Cited by 135
Cited by
ABC transporters: the power to change
Rees, D. C., Johnson, E., & Lewinson, O. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2646 · Cited by 1,450
Verghese, J., Abrams, J., Wang, Y., & Morano, K. A. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05018-11 · Cited by 575
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Hochheiser, I. V., Pilsl, M., Hagelueken, G., Moecking, J., Marleaux, M., Brinkschulte, R., Latz, E., Engel, C., & Geyer, M. (2022) · Nature · doi:10.1038/s41586-022-04467-w · Cited by 312
Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling
Erzberger, J. P., Mott, M. L., & Berger, J. M. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1115 · Cited by 308
Self-citationHsp104 and ClpB: protein disaggregating machines
Doyle, S. M., & Wickner, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.09.010 · Cited by 284
Metadata
- Authors
- Erzberger, J. P., & Berger, J. M.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2006-06-01
- Volume
- 35
- Issue
- 1
- Pages
- 93-114
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2121431496
- Cited by
- 758
- References
- 1
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Erzberger, J. P., & Berger, J. M. (2006). EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.35.040405.101933
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