The DOI matches its Crossref record.
Growth and Differentiation in the Hemopoietic System
Abstract
Hemopoiesis is regulated by a complex series of interactions, including interactions among hemopoietic cells themselves, hemopoietic cells and the extracellular matrix, hemopoietic cells and marrow stromal cells, and hemopoietic cells and growth factors. In vitro culture systems have allowed a reductionist approach to the solution of these various problems and have facilitated experiments at the mechanistic level. The hemopoietic system is organized hierarchically with multipotential self-renewing stem cells, committed progenitor cells, and mature cells. The various stimuli necessary for growth and development of these cells are rapidly being elucidated. The nature of commitment (or differentiation) remains an enigma, but model systems have been developed in which various aspects of this problem can be investigated. In this respect, growth and differentiation factors obviously have a major role to play. Now that many of these factors have been molecularly cloned (and pure target cell populations are available) their role in vivo and their mode of action can be examined.
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“MSCs derived from bone marrow (BM)-MSCs being able to ensure the growth and viability of hematopoietic stem cells in co-culture conditions without growth factor supplementation [5], [6].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [5]
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Caplan, A. I. (1991) · Journal of Orthopaedic Research · doi:10.1002/jor.1100090504 · Cited by 6,548
Mechanisms of mesenchymal stem/stromal cell function
Spees, J. L., Lee, R. H., & Gregory, C. A. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0363-7 · Cited by 891
Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche
Taichman, R. S. (2005) · Blood · doi:10.1182/blood-2004-06-2480 · Cited by 649
Biological functions of mesenchymal stem cells and clinical implications
Naji, A., Eitoku, M., Favier, B., Deschaseaux, F., Rouas-Freiss, N., & Suganuma, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03125-1 · Cited by 624
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., & Lemischka, I. R. (1991) · Cell · doi:10.1016/0092-8674(91)90010-v · Cited by 593
Metadata
- Authors
- Dexter, T. M., & Spooncer, E.
- Affiliations
- Cancer Research UK Manchester Institute (GB)
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1987-11
- Volume
- 3
- Issue
- 1
- Pages
- 423-441
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W2145931826
- Cited by
- 209
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 5 · 2017: 2 · 2016: 2 · 2015: 2 · 2013: 1 · 2012: 3
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- hematopoiesis, hematopoietic stem cells, hematopoietic differentiation, hematopoietic progenitor cells, growth factors, hematopoietic hierarchy, extracellular matrix, mesenchymal stem cells, lineage commitment, in vitro culture system
- MeSH terms
- Animals, Cell Differentiation, Growth Substances, Hematopoiesis, Hematopoietic Stem Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
