ABC Transporters: From Microorganisms to Man
Abstract
Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
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Functional eukaryotic ABC transporters contain two homologous halves, each with a transmembrane domain and an ATP-binding domain.
“Functional eukaryotic ABC transporters contain two homologous halves, each with a transmembrane domain (TMD) and an ATPbinding domain (ATP) [Higgins, 1992].”
From ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: Role in diagnosis and clinical correlations (2001) · cites this paper as Higgins, 1992
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References 118 · Cited by 3,985
- Authors
- Higgins, C. F.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- Higgins, Christopher F.
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1992-11
- Volume
- 8
- Issue
- 1
- Pages
- 67-113
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W2162097287
- Cited by
- 3,985
- References
- 118
- Citations by year
- 2026: 28 · 2025: 53 · 2024: 65 · 2023: 65 · 2022: 83 · 2021: 78 · 2020: 76 · 2019: 82 · 2018: 77 · 2017: 89 · 2016: 78 · 2015: 103 · 2014: 96 · 2013: 95 · 2012: 111
- FWCI
- 55.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- ABC transporters, membrane transport, phase separation, liquid-liquid phase separation, non-membrane compartments, cytoplasmic compartments
- MeSH terms
- Adenosine Triphosphatases, Adenosine Triphosphate, Amino Acid Sequence, Animals, Bacterial Outer Membrane Proteins, Binding Sites, Biological Transport, Active, Carrier Proteins, Cystic Fibrosis, Drug Resistance, Escherichia coli, Genes, Multigene Family, Humans, Intracellular Membranes, Ion Channels, Membrane Glycoproteins, Membrane Proteins, Molecular Sequence Data, Protein Conformation, Proteins, Substrate Specificity, Sequence Alignment, Sequence Homology, Amino Acid, Cystic Fibrosis Transmembrane Conductance Regulator, ATP Binding Cassette Transporter, Subfamily B, Member 1
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