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Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease
Abstract
BIOCHEMICAL ANALYSES OF ALZHEIMER BRAIN LESIONS LEAD TO THE IDENTIFICATION OF A� AND ITS PRECURSOR . . . . . . . . . . . . . . . . . . . 374 The Histopathology of Alzheimer's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374 Characterization of A � and �pp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 376 AL TERNA TIVE PROTEOLYTIC PROCESSING OF �PP AND THE GENERATION OF A� 378 GENETIC EVIDENCE IMPLICATES A� IN THE PATHOGENESIS OF FAMILIAL ALZHEIMER'S DISEASE 380 SEVERAL POTENTIAL FUNCTIONS HAVE BEEN ASCRIBED TO �PP . . . . . . . . . 383 CELL BIOLOGICAL STUDIES OF THE TRAFFICKING AND SECRETORY PROCESSING OF �PP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 385 �pp Traf icking in Polarized Epithelial Cells ........ . 389 SECRETORY PROCESSING OF �PP IS UNDER COMPLEX REGULATION BY FIRST MESSENGERS . . . . . ......... 391 UNDERSTANDING THE ROLE OF J3PP PROCESSING IN THE PATHOGENETIC CASCADE OF AD .. . .. . 393 CONCLUSION ... . ..... . 397
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Cited by
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Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506
Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., & Selkoe, D. J. (1999) · Nature · doi:10.1038/19077 · Cited by 1,916
Self-citationTwo amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Amyloid, the presenilins and Alzheimer’s disease
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Metadata
- Authors
- Selkoe, D. J.
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1994-11
- Volume
- 10
- Issue
- 1
- Pages
- 373-403
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W1967237003
- Cited by
- 747
- References
- 0
- FWCI
- 27.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Selkoe, D. J. (1994). Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease. Annual Review of Cell Biology. https://doi.org/10.1146/annurev.cb.10.110194.002105
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
