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Unconventional Myosins
Abstract
Myosins are molecular motors that upon interaction with actin filaments convert energy from ATP hydrolysis into mechanical force. Evidence has emerged for the existence of a large, widely expressed and evolutionarily ancient superfamily of myosin genes. In addition to the well-catheterized conventional, filament-forming, two-headed myosin-II of muscle and nonmuscle cells, at least ten additional classes of myosins have been identified. In vertebrates, at least seven of the eleven classes are expressed, and many myosins can be expressed in a single cell type. This review summarizes known structural and functional features of these novel unconventional myosins.
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“Many myosins are inhibited for actin interaction in a light chain-dependent manner by sequences downstream of their motor domains (Cross et al., 1988; Mooseker and Cheney, 1995).”
From Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules (1998) · cites this paper as Mooseker and Cheney, 1995
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Berg, J. S., Powell, B. C., & Cheney, R. E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.4.780 · Cited by 767
“With the addition of these new myosins-I, each of the four previously defined myosin-I subclasses (Mooseker and Cheney, 1995) now contains two genes in humans.”
BackgroundSelf-citationMyosin VI is an actin-based motor that moves backwards
Wells, A. L., Lin, A. W., Chen, L.-Q., Safer, D., Cain, S. M., Hasson, T., Carragher, B. O., Milligan, R. A., & Sweeney, H. L. (1999) · Nature · doi:10.1038/46835 · Cited by 680
Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction
Mermall, V., Post, P. L., & Mooseker, M. S. (1998) · Science · doi:10.1126/science.279.5350.527 · Cited by 654
Self-citationLytic Cycle ofToxoplasma gondii
Black, M. W., & Boothroyd, J. C. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.607-623.2000 · Cited by 554
Unconventional Myosins in Inner-Ear Sensory Epithelia
Hasson, T., Gillespie, P. G., Garcı́a, J. A., MacDonald, R. B., Zhao, Y.-D., Yee, A. G., Mooseker, M. S., & Corey, D. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1287 · Cited by 538
“Despite their apparent similarity of function, at least a dozen distinct classes of myosin separated in ancient progenitors, and most of these classes have been retained in fungi, amoebas, plants, invertebrates, and vertebrates (Mooseker and Cheney, 1995).”
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Metadata
- Authors
- Mooseker, M. S., & Cheney, R. E.
- Affiliations
- Yale University (US)
- ORCID
- Cheney, Richard E.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1995-11
- Volume
- 11
- Issue
- 1
- Pages
- 633-675
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W4234290082
- Cited by
- 370
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 10
- FWCI
- 38.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01dk038979-05)
- National Institute of General Medical Sciences (GM25387)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38979, DK-34989, P30DK034989)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- unconventional myosins, myosin superfamily, molecular motors, F-actin, ATP hydrolysis, myosin II, myosin structure, myosin function
- MeSH terms
- Acanthamoeba, Amino Acid Sequence, Animals, Deafness, Drosophila, Humans, Molecular Sequence Data, Myosins, Phylogeny, Saccharomyces cerevisiae, Swine, Arabidopsis, Sequence Homology, Amino Acid, Mice
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