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STRUCTURE, FUNCTION AND REGULATION OF THE VACUOLAR (H+)-ATPase
Abstract
▪ Abstract The vacuolar (H+)-ATPases (or V-ATPases) function in the acidification of intracellular compartments in eukaryotic cells. The V-ATPases are multisubunit complexes composed of two functional domains. The peripheral V 1 domain, a 500-kDa complex responsible for ATP hydrolysis, contains at least eight different subunits of molecular weight 70-13 (subunits A-H). The integral V 0 domain, a 250-kDa complex, functions in proton translocation and contains at least five different subunits of molecular weight 100-17 (subunits a-d). Biochemical and genetic analysis has been used to identify subunits and residues involved in nucleotide binding and hydrolysis, proton translocation, and coupling of these activities. Several mechanisms have been implicated in the regulation of vacuolar acidification in vivo, including control of pump density, regulation of assembly of V 1 and V 0 domains, disulfide bond formation, activator or inhibitor proteins, and regulation of counterion conductance. Recent information concerning targeting and regulation of V-ATPases has also been obtained.
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Sturgill-Koszycki, S., Schlesinger, P. H., Chakraborty, P., Haddix, P. L., Collins, H. L., Fok, A. K., Allen, R. D., Gluck, S. L., Heuser, J., & Russell, D. G. (1994) · Science · doi:10.1126/science.8303277 · Cited by 1,302
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Metadata
- Authors
- Stevens, T. H., & Forgac, M.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1997-11
- Volume
- 13
- Issue
- 1
- Pages
- 779-808
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2616345050
- Cited by
- 588
- References
- 1
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: STRUCTURE, FUNCTION AND REGULATION OF THE VACUOLAR (H+)-ATPase. https://app.cochat.ai/papers/10.1146/annurev.cellbio.13.1.779
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- Stevens, T. H., & Forgac, M. (1997). STRUCTURE, FUNCTION AND REGULATION OF THE VACUOLAR (H+)-ATPase. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.13.1.779
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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