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RNA TRANSLATION IN AXONS

Piper, Michael, Holt, Christine·2004·Annual Review of Cell and Developmental Biology
DOI 10.1146/annurev.cellbio.20.010403.111746PMC PMC3682640
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Abstract

▪ Abstract The cell body has classically been considered the exclusive source of axonal proteins. However, significant evidence has accumulated recently to support the view that protein synthesis can occur in axons themselves, remote from the cell body. Indeed, local translation in axons may be integral to aspects of synaptogenesis, long-term facilitation, and memory storage in invertebrate axons, and for growth cone navigation in response to environmental stimuli in developing vertebrate axons. Here we review the evidence supporting mRNA translation in axons and discuss the potential roles that local protein synthesis may play during development and subsequent neuronal function. We advance the view that local translation provides a rapid supply of nascent proteins in restricted axonal compartments that can potentially underlie long-term responses to transient stimuli.

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Authors
Piper, M., & Holt, C.
Venue
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Published
2004-11-01
Volume
20
Issue
1
Pages
505-523
ISSN
  • 1081-0706
  • 1530-8995
DOI
10.1146/annurev.cellbio.20.010403.111746
PMC
PMC3682640
Cited by
171
References
1
Language
en

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