The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Genetic Polymorphism in Heterogeneous Environments: The Age of Genomics
Abstract
The selective mechanisms for maintaining polymorphism in natural populations has been the subject of theory, experiments, and review over the past half century. Advances in molecular genetic techniques have provided new insight into many examples of balancing selection. In addition, new theoretical developments demonstrate how diversifying selection over environments may maintain polymorphism. Tests for balancing selection in the current generation, the recent past, and the distant past provide a comprehensive approach for evaluating selective impacts. In particular, sequenced-based tests provide new ways to evaluate the long-term impact of selection on particular genes and the overall genome in natural populations. Overall, there appear to be many loci exhibiting the signal of adaptive directional selection from genomic scans, but the present evidence suggests that the proportion of loci where polymorphism is maintained by environmental heterogeneity is low. However, as more molecular genetic details become available, more examples of polymorphism maintained by selection in heterogeneous environments may be found.
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Citations
Cites
Hitchhiking Under Positive Darwinian Selection
Fay, J. C., & Wu, C.-I. (2000) · Genetics · doi:10.1093/genetics/155.3.1405 · Cited by 1,819
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
Lamason, R. L., Mohideen, M.-A. P. K., Mest, J. R., Wong, A. C., Norton, H. L., Aros, M. C., Jurynec, M. J., Mao, X., Humphreville, V. R., Humbert, J. E., et al. (2005) · Science · doi:10.1126/science.1116238 · Cited by 1,043
Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes
Stephens, J. C., Reich, D. E., Goldstein, D. B., Shin, H. D., Smith, M. W., Carrington, M., Winkler, C., Huttley, G. A., Allikmets, R., Schriml, L., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301867 · Cited by 520
Haemoglobin C protects against clinical Plasmodium falciparum malaria
Modiano, D., Luoni, G., Sirima, B. S., Simporé, J., Verra, F., Konaté, A., Rastrelli, E., Olivieri, A., Calissano, C., Paganotti, G. M., et al. (2001) · Nature · doi:10.1038/35104556 · Cited by 381
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection
Ohashi, J., Naka, I., Patarapotikul, J., Hananantachai, H., Brittenham, G., Looareesuwan, S., Clark, A. G., & Tokunaga, K. (2004) · The American Journal of Human Genetics · doi:10.1086/421330 · Cited by 137
Recent History of Melanism in American Peppered Moths
Grant, B. S., & Wiseman, L. L. (2002) · Journal of Heredity · doi:10.1093/jhered/93.2.86 · Cited by 77
On the worldwide spread of an insecticide resistance gene: a role for local selection
LABBE, P., LENORMAND, T., & RAYMOND, M. (2005) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2005.00938.x · Cited by 75
Allelic Melanism in American and British Peppered Moths
Grant, B. S. (2004) · Journal of Heredity · doi:10.1093/jhered/esh022 · Cited by 18
Cited by
KORSTEN, P., MUELLER, J. C., HERMANNSTÄDTER, C., BOUWMAN, K. M., DINGEMANSE, N. J., DRENT, P. J., LIEDVOGEL, M., MATTHYSEN, E., Van OERS, K., Van OVERVELD, T., et al. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2009.04518.x · Cited by 123
Metadata
- Authors
- Hedrick, P. W.
- Venue
- Annual Review of Ecology, Evolution, and Systematics
- Publisher
- Annual Reviews
- Published
- 2006-12-01
- Volume
- 37
- Issue
- 1
- Pages
- 67-93
- ISSN
- 1543-592X (ISSN-L)
- 1545-2069
- OpenAlex
- W2095672786
- Cited by
- 398
- References
- 9
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
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