The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
S ELECTIVE T OXICITY OF N EONICOTINOIDS A TTRIBUTABLE TO S PECIFICITY OF I NSECT AND M AMMALIAN N ICOTINIC R ECEPTORS
Abstract
▪ Abstract Neonicotinoids, the most important new class of synthetic insecticides of the past three decades, are used to control sucking insects both on plants and on companion animals. Imidacloprid (the principal example), nitenpyram, acetamiprid, thiacloprid, thiamethoxam, and others act as agonists at the insect nicotinic acetylcholine receptor (nAChR). The botanical insecticide nicotine acts at the same target without the neonicotinoid level of effectiveness or safety. Fundamental differences between the nAChRs of insects and mammals confer remarkable selectivity for the neonicotinoids. Whereas ionized nicotine binds at an anionic subsite in the mammalian nAChR, the negatively tipped (“magic” nitro or cyano) neonicotinoids interact with a proposed unique subsite consisting of cationic amino acid residue(s) in the insect nAChR. Knowledge reviewed here of the functional architecture and molecular aspects of the insect and mammalian nAChRs and their neonicotinoid-binding site lays the foundation for continued development and use of this new class of safe and effective insecticides.
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Citations
Cites
Pest Control Agents from Natural Products
Ujváry, I. (2010) · Hayes' Handbook of Pesticide Toxicology · doi:10.1016/b978-0-12-374367-1.00003-3 · Cited by 81
Cited by
Environmental fate and exposure; neonicotinoids and fipronil
Bonmatin, J.-M., Giorio, C., Girolami, V., Goulson, D., Kreutzweiser, D. P., Krupke, C., Liess, M., Long, E., Marzaro, M., Mitchell, E. A. D., et al. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3332-7 · Cited by 1,372
Neonicotinoid Metabolism: Compounds, Substituents, Pathways, Enzymes, Organisms, and Relevance
Casida, J. E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102438c · Cited by 375
Self-citationFlupyradifurone: a brief profile of a new butenolide insecticide
Nauen, R., Jeschke, P., Velten, R., Beck, M. E., Ebbinghaus‐Kintscher, U., Thielert, W., Wölfel, K., Haas, M., Kunz, K., & Raupach, G. (2015) · Pest Management Science · doi:10.1002/ps.3932 · Cited by 351
Pisa, L., Goulson, D., Yang, E.-C., Gibbons, D., Sánchez-Bayo, F., Mitchell, E., Aebi, A., van der Sluijs, J., MacQuarrie, C. J. K., Giorio, C., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0341-3 · Cited by 308
Sadaria, A. M., Supowit, S. D., & Halden, R. U. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b01032 · Cited by 185
Metadata
- Authors
- Tomizawa, M., & Casida, J. E.
- Venue
- Annual Review of Entomology
- Publisher
- Annual Reviews
- Published
- 2003-01
- Volume
- 48
- Issue
- 1
- Pages
- 339-364
- ISSN
- 0066-4170 (ISSN-L)
- 1545-4487
- OpenAlex
- W2101488656
- Cited by
- 899
- References
- 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: S ELECTIVE T OXICITY OF N EONICOTINOIDS A TTRIBUTABLE TO S PECIFICITY OF I NSECT AND M AMMALIAN N ICOTINIC R ECEPTORS. https://app.cochat.ai/papers/10.1146/annurev.ento.48.091801.112731
- The paper
- Tomizawa, M., & Casida, J. E. (2003). S ELECTIVE T OXICITY OF N EONICOTINOIDS A TTRIBUTABLE TO S PECIFICITY OF I NSECT AND M AMMALIAN N ICOTINIC R ECEPTORS. Annual Review of Entomology. https://doi.org/10.1146/annurev.ento.48.091801.112731
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