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Cited by 559

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

GENETICS OF HUMAN CANCER

Knudson, Alfred G.·1986·Annual Review of Genetics

Abstract

Study of hereditary cancer in humans has revealed new mechanisms in carcinogenesis. In particular, a new class of cancer gene, recessive in oncogenesis, accounts for dominantly transmitted predisposition to some cancers, and may play a primary role in the nonhereditary forms of most cancers. Comparison of polymorphic markers in lymphocytes and tumors has permitted the in vivo observation of somatic events that lead to genetic recombination. The tissue specificities of these recessive cancer genes suggest that their normal alleles, like those of oncogenes, play important roles in normal development.

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Crossref · 10.1146/annurev.ge.20.120186.001311

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Metadata

Authors
Knudson, A. G.
Venue
Annual Review of Genetics
Published
1986-12
Volume
20
Issue
1
Pages
231-251
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2153371056
Cited by
559
References
2
FWCI
34.07
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.