Genetic Control of Programmed Cell Death During Animal Development
Open accessAbstract
The elimination of unwanted cells by programmed cell death is a common feature of animal development. Genetic studies in the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the mouse have not only revealed the molecular machineries that cause the programmed demise of specific cells, but have also allowed us to get a glimpse of the types of pathways that regulate these machineries during development. Rather than serving as a broad overview of programmed cell death during development, this review focuses on recent advances in our understanding of the regulation of specific programmed cell death events during nematode, fly, and mouse development. Recent studies have revealed that many of the regulatory pathways involved play additional important roles in development, which confirms that the programmed cell death fate is an integral aspect of animal development.
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RCD can occur in the absence of any exogenous environmental perturbation, operating as a built-in effector of physiological programs for development or tissue turnover.
“On the one hand, RCD can occur in the absence of any exogenous environmental perturbation, hence operating as a built-in effector of physiological programs for development or tissue turnover [6, 18].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [18]
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References 247 · Cited by 173
Research works printed but not linked: 2
- [23]Bouillet P Purton JF Godfrey DI Zhang LC Coultas L BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Nature 2002 415 922 926 11859372
- [222]Wurgler FE Ullrich H Radiaosensitivity of embryonic stages 1976 London; New York Academic Press 1269 1298
- Authors
- Conradt, B.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Conradt, Barbara
- ORCID
- Conradt, Barbara
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2009-12-01
- Volume
- 43
- Issue
- 1
- Pages
- 493-523
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- PMC
- PMC2806233
- OpenAlex
- W2120002749
- Cited by
- 173
- References
- 247
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 7 · 2013: 15 · 2012: 19
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Lomonosov Moscow State University
- National Institute of General Medical Sciences (R01GM069950, R01GM076651)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- programmed cell death, apoptosis, animal development, Caenorhabditis elegans, Drosophila melanogaster, mice
- MeSH terms
- Animals, Autophagy, Drosophila melanogaster, Caenorhabditis elegans, Apoptosis, Gene Expression Regulation, Developmental, Mice
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