The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
The Biochemistry and Cell Biology of Antigen Processing and Presentation
Abstract
T lymphocytes with alpha beta receptors recognize antigen in association with the polymorphic products of the class I and class II loci of the major histocompatibility complex (MHC). This presentation of antigen results from the intracellular generation of protein fragments, and the binding and transport to the cell surface of these peptides in stable association with the MHC class I and class II molecules. Each class of MHC molecule appears specialized for capture of peptides present in a particular intracellular compartment. We describe here the structural basis of peptide-MHC molecule interaction, the differences in biochemical behavior that focus the two classes of MHC molecules on peptides of distinct size and location, and the cell biology of MHC molecule transport, peptide generation, and intracellular movement. The importance of conformational changes accompanying peptide binding that affect subunit stability of MHC molecules, and the relationship between these changes and the handling of proteins by intracellular chaperones, are emphasized as key features in the operation of the class I and class II presentation pathways.
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Cites
Structure of the human class I histocompatibility antigen, HLA-A2
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329506a0 · Cited by 3,472
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
ZINKERNAGEL, R. M., & DOHERTY, P. C. (1974) · Nature · doi:10.1038/248701a0 · Cited by 2,095
Antigen-specific interaction between T and B cells
Lanzavecchia, A. (1985) · Nature · doi:10.1038/314537a0 · Cited by 1,412
Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry
Hunt, D. F., Henderson, R. A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A. L., Appella, E., & Engelhard, V. H. (1992) · Science · doi:10.1126/science.1546328 · Cited by 1,198
Binding of immunogenic peptides to Ia histocompatibility molecules
Babbitt, B. P., Allen, P. M., Matsueda, G., Haber, E., & Unanue, E. R. (1985) · Nature · doi:10.1038/317359a0 · Cited by 1,195
A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules
Brown, J. H., Jardetzky, T., Saper, M. A., Samraoui, B., Bjorkman, P. J., & Wiley, D. C. (1988) · Nature · doi:10.1038/332845a0 · Cited by 1,147
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution
Saper, M. A., Bjorkman, P. J., & Wiley, D. C. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90567-p · Cited by 1,077
Sequence analysis of peptides bound to MHC class II molecules
Rudensky, A. Y., Preston-Hurlburt, P., Hong, S.-C., Barlow, A., & Janeway, C. A. (1991) · Nature · doi:10.1038/353622a0 · Cited by 1,075
β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
Zijlstra, M., Bix, M., Simister, N. E., Loring, J. M., Raulet, D. H., & Jaenisch, R. (1990) · Nature · doi:10.1038/344742a0 · Cited by 1,012
Cited by
Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994) · Cell · doi:10.1016/s0092-8674(94)90462-6 · Cited by 2,524
Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK
Zhu, X., Zhao, X., Burkholder, W. F., Gragerov, A., Ogata, C. M., Gottesman, M. E., & Hendrickson, W. A. (1996) · Science · doi:10.1126/science.272.5268.1606 · Cited by 1,258
Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228
Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
Sette, A., & Sidney, J. (1999) · Immunogenetics · doi:10.1007/s002510050594 · Cited by 635
Leone, P., Shin, E.-C., Perosa, F., Vacca, A., Dammacco, F., & Racanelli, V. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt184 · Cited by 553
Metadata
- Authors
- Germain, R.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1993-01-01
- Volume
- 11
- Issue
- 1
- Pages
- 403-450
- ISSN
- 0732-0582 (ISSN-L)
- OpenAlex
- W2107857115
- Cited by
- 1,020
- References
- 133
- FWCI
- 37.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
