The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition
Abstract
V(D)J recombination proceeds through a series of protein:DNA complexes mediated in part by the RAG1 and RAG2 proteins. These proteins are responsible for sequence-specific DNA recognition and DNA cleavage, and they appear to perform multiple postcleavage roles in the reaction as well. Here we review the interaction of the RAG proteins with DNA, the chemistry of the cleavage reaction, and the higher order complexes in which these events take place. We also discuss postcleavage functions of the RAG proteins, including recent evidence indicating that they initiate the process of coding end processing by nicking hairpin DNA termini. Finally, we discuss the evolutionary and functional implications of the finding that RAG1 and RAG2 constitute a transposase, and we consider RAG protein biochemistry in the context of several bacterial transposition systems. This suggests a model of the RAG protein active site in which two divalent metal ions serve alternating and opposite roles as activators of attacking hydroxyl groups and stabilizers of oxyanion leaving groups.
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Citations
Cites
A general two-metal-ion mechanism for catalytic RNA
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The Homeodomain Region of Rag-1 Reveals the Parallel Mechanisms of Bacterial and V(D)J Recombination
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Cited by
Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C.-H., et al. (2008) · Nature · doi:10.1038/nature06866 · Cited by 1,072
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
Yu, K., Chedin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. R. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 746
Recombination centres and the orchestration of V(D)J recombination
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Self-citationThe immune gene repertoire encoded in the purple sea urchin genome
Hibino, T., Loza-Coll, M., Messier, C., Majeske, A. J., Cohen, A. H., Terwilliger, D. P., Buckley, K. M., Brockton, V., Nair, S. V., Berney, K., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.065 · Cited by 630
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Metadata
- Authors
- Fugmann, S. D., Lee, A. I., Shockett, P. E., Villey, I. J., & Schatz, D. G.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 18
- Issue
- 1
- Pages
- 495-527
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2103425962
- Cited by
- 647
- References
- 5
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fugmann, S. D., Lee, A. I., Shockett, P. E., Villey, I. J., & Schatz, D. G. (2000). The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.18.1.495
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
