The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Abstract
Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain tolerance via the regulation of lymphocyte proliferation, differentiation, and survival. In addition, TGF-β controls the initiation and resolution of inflammatory responses through the regulation of chemotaxis, activation, and survival of lymphocytes, natural killer cells, dendritic cells, macrophages, mast cells, and granulocytes. The regulatory activity of TGF-β is modulated by the cell differentiation state and by the presence of inflammatory cytokines and costimulatory molecules. Collectively, TGF-β inhibits the development of immunopathology to self or nonharmful antigens without compromising immune responses to pathogens. This review highlights the findings that have advanced our understanding of TGF-β in the immune system and in disease.
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Cites
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
The biology and function of fibroblasts in cancer
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Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
Transforming growth factor-β induces development of the TH17 lineage
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Metadata
- Authors
- Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2006-04-01
- Volume
- 24
- Issue
- 1
- Pages
- 99-146
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2113313714
- Cited by
- 2,206
- References
- 17
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2006). TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.24.021605.090737
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
