The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Aire
Abstract
Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECED have revealed that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting ectopic expression of a large repertoire of transcripts encoding proteins normally restricted to differentiated organs residing in the periphery. The absence of Aire results in impaired clonal deletion of self-reactive thymocytes, which escape into the periphery and attack a variety of organs. In addition, Aire is a proapoptotic factor, expressed at the final maturation stage of thymic medullary epithelial cells, a function that may promote cross-presentation of the antigens encoded by Aire-induced transcripts in these cells. Transcriptional regulation by Aire is unusual in being very broad, context-dependent, probabilistic, and noisy. Structure/function analyses and identification of its interaction partners suggest that Aire may impact transcription at several levels, including nucleosome displacement during elongation and transcript splicing or other aspects of maturation.
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Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Meager, A., Visvalingam, K., Peterson, P., Möll, K., Murumägi, A., Krohn, K., Eskelin, P., Perheentupa, J., Husebye, E., Kadota, Y., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030289 · Cited by 453
Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J. M., Takayanagi, H., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.018 · Cited by 433
The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation
Bottomley (2001) · Nature Structural Biology · doi:10.1038/89675 · Cited by 224
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Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
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Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.014 · Cited by 1,620
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Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 784
Puel, A., Döffinger, R., Natividad, A., Chrabieh, M., Barcenas-Morales, G., Picard, C., Cobat, A., Ouachée-Chardin, M., Toulon, A., Bustamante, J., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091983 · Cited by 733
Kisand, K., Bøe Wolff, A. S., Podkrajšek, K. T., Tserel, L., Link, M., Kisand, K. V., Ersvaer, E., Perheentupa, J., Erichsen, M. M., Bratanic, N., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091669 · Cited by 677
Metadata
- Authors
- Mathis, D., & Benoist, C.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2009-04-01
- Volume
- 27
- Issue
- 1
- Pages
- 287-312
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W4232229546
- Cited by
- 570
- References
- 4
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
