The IRF Family Transcription Factors in Immunity and Oncogenesis
Abstract
The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. Subsequent studies over the past two decades have revealed the versatile and critical functions performed by this transcription factor family. Indeed, many IRF members play central roles in the cellular differentiation of hematopoietic cells and in the regulation of gene expression in response to pathogen-derived danger signals. In particular, the advances made in understanding the immunobiology of Toll-like and other pattern-recognition receptors have recently generated new momentum for the study of IRFs. Moreover, the role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
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Interferon regulatory factors (IRFs), including Irf1, Irf2, Irf5, Irf7, and Irf8, are responsible for activating immune response.
“including several interferon regulatory factors (IRFs)—Irf1, Irf2, Irf5, Irf7, and Irf8—responsible for activating immune response (34).”
From Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice (2025) · cites this paper as [34]
Borzoi correctly predicts upregulation of SHTN1 expression owing to the creation of a CEBP binding motif.
“Borzoi correctly predicts the upregulation of SHTN1 expression owing to the creation of a CEBP binding motif69–72 (see Supplementary Fig. 9a and Extended Data Fig. 6a,b for additional examples).”
From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [72]
The IRF family contains key regulators of neural immune pathways expressed in glial cells.
“which contains key regulators of neural immune pathways expressed in glial cells31.”
From Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders (2021) · cites this paper as [31]
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References 355 · Cited by 1,259
- Authors
- Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T.
- Affiliations
- The University of Tokyo (JP)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 535-584
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2147640266
- Cited by
- 1,259
- References
- 355
- Citations by year
- 2026: 41 · 2025: 67 · 2024: 61 · 2023: 76 · 2022: 65 · 2021: 84 · 2020: 70 · 2019: 60 · 2018: 66 · 2017: 80 · 2016: 75 · 2015: 72 · 2014: 101 · 2013: 79 · 2012: 68
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- interferon regulatory factors, IRF transcription factors, type I interferon, innate immunity, Toll-like receptors, pattern recognition receptors, hematopoietic differentiation, damage-associated molecular patterns, cell cycle regulation, apoptosis, carcinogenesis, cancer susceptibility
- MeSH terms
- Animals, Cell Differentiation, Humans, Immunity, Immunity, Innate, Neoplasms, Signal Transduction, Models, Immunological, Interferon Regulatory Factors
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