The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
MHC Class-II Molecules and Autoimmunity
Abstract
Molecular and genetic studies of HLA class-II genes provide new insights into the basis for MHC associations with autoimmunity. Polymorphisms among class-II genes identify specific haplotypes associated with autoimmune diseases such as type-I diabetes, rheumatoid arthritis, celiac disease, and pemphigus vulgaris. In some cases, single genes within those haplotypes are themselves implicated in disease susceptibility. Interactions, both cis and trans, between candidate susceptibility genes suggest a number of possible mechanisms critical for autoimmune triggering events involving class-II molecules. Amino acid sequence comparisons between products of candidate susceptibility genes and other class-II genes pinpoint a limited number of critical sites within HLA molecules which appear to be responsible for pathogenic events.
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Citations
Cites
Eisenbarth (1986) · doi:10.1056/nejm198605223142106 · Cited by 1,659
Cited by
HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk
Erlich, H., Valdes, A. M., Noble, J., Carlson, J. A., Varney, M., Concannon, P., Mychaleckyj, J. C., Todd, J. A., Bonella, P., Fear, A. L., et al. (2008) · Diabetes · doi:10.2337/db07-1331 · Cited by 790
Self-citationAutoimmune Thyroid Disease: Further Developments in Our Understanding*
WEETMAN, A. P., & McGREGOR, A. M. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-6-788 · Cited by 658
Rewers, M., Bugawan, T. L., Norris, J. M., Blair, A., Beaty, B., Hoffman, M., McDuffie, R. S., Hamman, R. F., Klingensmith, G., Eisenbarth, G. S., et al. (1996) · Diabetologia · doi:10.1007/s001250050514 · Cited by 422
Self-citationImmunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
Martin, R., McFarland, H. F., & Boggs, J. M. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509084683 · Cited by 376
Semple, J., Milev, Y., Cosgrave, D., Mody, M., Hornstein, A., Blanchette, V, & Freedman, J. (1996) · Blood · doi:10.1182/blood.v87.10.4245.bloodjournal87104245 · Cited by 363
Metadata
- Authors
- Nepom, G. T., & Erlich, H.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1991-04
- Volume
- 9
- Issue
- 1
- Pages
- 493-525
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2174570609
- Cited by
- 519
- References
- 1
- FWCI
- 21.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nepom, G. T., & Erlich, H. (1991). MHC Class-II Molecules and Autoimmunity. Annual Review of Immunology. https://doi.org/10.1146/annurev.iy.09.040191.002425
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
