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Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction
Abstract
Rejection of transplanted tissue allografts results from T-cell recognition of histocompatibility antigens expressed by cells of the donor graft. This review focuses on the phenotype, specificity, and function of the T cells mediating rejection responses against skin allografts, and on the immune mechanisms by which host T cells are either activated or rendered non-responsive by cellular populations within the graft. We review the cellular basis for rejection responses across limited class-I and class-II major histocompatibility differences, as well as the specificity of the rejection response itself.
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Citations
Cited by
T cell Allorecognition Pathways in Solid Organ Transplantation
Siu, J. H. Y., Surendrakumar, V., Richards, J. A., & Pettigrew, G. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02548 · Cited by 223
Allorecognition by T Lymphocytes and Allograft Rejection
Marino, J., Paster, J., & Benichou, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00582 · Cited by 221
Metadata
- Authors
- Rosenberg, A. S., & Singer, A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1992-04
- Volume
- 10
- Issue
- 1
- Pages
- 333-360
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2102942510
- Cited by
- 293
- References
- 0
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction. https://app.cochat.ai/papers/10.1146/annurev.iy.10.040192.002001
- The paper
- Rosenberg, A. S., & Singer, A. (1992). Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction. Annual Review of Immunology. https://doi.org/10.1146/annurev.iy.10.040192.002001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
