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Elastase in Tissue Injury
Abstract
This article surveys elastinolytic proteinases in man, excluding enzymes of the pancreas and digestive tract. Special emphasis is placed on the elastase of polymorphonuclear neutrophils (PMN). The properties of this latter enzyme, its target molecules in plasma and connective tissues, and its endogenous regulators are briefly discussed. Persistent activity of the enzyme, even in the presence of its regulatory inhibitors, is explained. The chapter closes with a brief discussion of several pulmonary diseases in which elastase-mediated tissue injury is thought to play a role.
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Citations
Cited by
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Tumor interactions with the vasculature: angiogenesis and tumor metastasis
Blood, C. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(90)90014-r · Cited by 593
Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584
The role of neutrophil elastase in acute lung injury
Kawabata, K., Hagio, T., & Matsuoka, S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02182-9 · Cited by 337
Metadata
- Authors
- Janoff, A.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1985-02
- Volume
- 36
- Issue
- 1
- Pages
- 207-216
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2150548162
- Cited by
- 501
- References
- 0
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Elastase in Tissue Injury. https://app.cochat.ai/papers/10.1146/annurev.me.36.020185.001231
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- Janoff, A. (1985). Elastase in Tissue Injury. Annual Review of Medicine. https://doi.org/10.1146/annurev.me.36.020185.001231
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
