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Serum Creatinine and Renal Function
Abstract
Serum creatinine is widely interpreted as a measure only of renal function; however, the serum level reflects not only renal excretion, but also the generation, intake, and metabolism of creatinine. In this review, we demonstrate that serum creatinine does not provide an adequate estimate of glomerular filtration rate (GFR), and contrary to recent teachings, that the slope of the reciprocal of serum creatinine vs time does not permit an accurate assessment of the rate of progression of renal disease. In clinical investigation, it is essential to utilize more accurate and sensitive measures of renal function to estimate GFR and progression. As effective treatments for progressive renal diseases are discovered, it will also be necessary to employ these measurements in clinical practice.
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Cited by
A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction
Rhee, E. P., Clish, C. B., Ghorbani, A., Larson, M. G., Elmariah, S., McCabe, E., Yang, Q., Cheng, S., Pierce, K., Deik, A., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012101006 · Cited by 307
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies
Jin, Q., & Ma, R. C. W. (2021) · Cells · doi:10.3390/cells10112832 · Cited by 252
Metadata
- Authors
- Levey, A. S., Perrone, R. D., & Madias, N. E.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1988-02
- Volume
- 39
- Issue
- 1
- Pages
- 465-490
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2180745593
- Cited by
- 605
- References
- 0
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- closed
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Serum Creatinine and Renal Function. https://app.cochat.ai/papers/10.1146/annurev.me.39.020188.002341
- The paper
- Levey, A. S., Perrone, R. D., & Madias, N. E. (1988). Serum Creatinine and Renal Function. Annual Review of Medicine. https://doi.org/10.1146/annurev.me.39.020188.002341
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
